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The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Certain drugs that block specific enzymes can help treat prostate diseases.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

*Acorus calamus* has many medicinal benefits but needs more safety research.

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Use finasteride, dutasteride, and minoxidil for hair loss treatment.

Human hair has a protective lipid layer that can be damaged by moisture and treatments, affecting hair growth and health.

Tinea capitis is a common scalp infection causing hair loss, mostly in young children.

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

New compounds may soon be tested to treat excessive hair growth in women.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

Gastric exclusion surgery caused major weight loss and health improvements but led to some anemia and vitamin deficiencies.

Putting ketoconazole on the skin can help mice grow hair.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.