research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease
Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.
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research Cornification
Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.
research Triptolide Shows Strong Efficacy and Safe Profile in Topical Treatment of Actinic Keratosis Lesions in UV-B-Induced Mouse Model
Triptolide effectively and safely reduces actinic keratosis lesions in mice.
research Growth Factors in Hair Organ Development and the Hair Growth Cycle
Growth factors are crucial for hair development and could help treat hair diseases.
research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications
Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.
research Human Hair Follicles Can Smell: OR2AT4-Mediated Hair Growth Regulation
Human hair follicles have a scent receptor that can influence hair growth.
research Molecular and Cellular Characterization of Avian Reticulate Scales and the Evolutionary Development of Skin Appendages in Foot Soles
Bird foot scales develop differently and can repair but not fully regenerate due to the lack of specialized stem cell areas.
research Physiological Doses of Red Light Induce IL-4 Release in Cocultures Between Human Keratinocytes and Immune Cells
Red light at 627 nm can safely trigger IL-4 release in skin cells, potentially helping treat inflammatory skin conditions.
research Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss
Fat-derived stem cells and their secretions show promise for treating skin aging and hair loss.
research Helminth Protein Enhances Wound Healing by Inhibiting Fibrosis and Promoting Tissue Regeneration
Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.
research Hair Follicle and Interfollicular Epidermal Stem Cells Make Varying Contributions to Wound Regeneration
Different skin stem cells help heal wounds, with hair follicle cells becoming more important over time.
research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures
The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.
research Honokiol Protects Skin Cells Against Inflammation, Collagenolysis, Apoptosis, and Senescence Caused by Cigarette Smoke Damage
Honokiol helps protect skin from damage and aging caused by cigarette smoke.
research Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism
The skin's microbiome helps hair regrow by boosting certain cell signals and metabolism.
research Anthralin (Dithranol) in Dermatology
Anthralin is effective for psoriasis and alopecia with minimal systemic side effects but can irritate the skin.
research Alteration of Skin Wound Healing in Keratinocyte-Specific Mediator Complex Subunit 1 Null Mice
MED1 affects skin wound healing differently in young and old mice.
research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression
The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.
research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)
A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.
research Activation of the Human Transient Receptor Potential Vanilloid Subtype 1 by Essential Oils
Certain essential oils can activate a human skin receptor, potentially helping with skin disorders.
research Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene
A specific gene mutation causes Olmsted syndrome.
research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation
Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.
research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin
EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.
research Heme Oxygenase and the Skin in Health and Disease
HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.
research Skin Biology: Understanding Biological Targets for Improving Appearance
The document concludes that a deeper understanding of skin aging and photodamage is needed to create better skin treatments.
research A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective
Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.
research WWOX Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin
WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.
research Cyclin-Dependent Kinase 4 Expression Alters the Number of Keratinocyte Stem Cells in the Mouse Hair Follicle
Changing CDK4 levels affects the number of stem cells in mouse hair follicles.
research Pannexin 3 Regulates Skin Development via Epiprofin
Pannexin 3 helps skin and hair growth by controlling a protein called Epiprofin.
research Overexpression of Hypoxia-Inducible Factor-1α in Hidradenitis Suppurativa: The Link Between Deviated Immunity and Metabolism
Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.
research Targeted Deletion of Crif1 in Mouse Skin Epidermis Impairs Skin Homeostasis
Removing the Crif1 gene in mouse skin disrupts skin balance and hair growth.