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Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Different types of stem cells and their environments are key to skin repair and maintenance.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Stem cells from hair follicles can safely treat hair loss.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.

New methods have greatly improved our understanding of stem cell behavior and roles in the body.

Human hair follicle stem cells can turn into multiple cell types but lose some of this ability after being grown in the lab for a long time.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.

Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.

Single Blimp1+ cells can create functional sebaceous gland organoids in the lab.

Activin activation in skin cells speeds up wound healing without affecting scar quality.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.