34 citations
,
June 2005 in “Developmental dynamics” Runx3 helps determine hair shape.
23 citations
,
April 2015 in “The American journal of pathology” Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.
4 citations
,
April 2019 in “Micron” Fetal hair follicles have melanocytes with melanosomes at different stages, which are broken down into pigment particles in keratinocytes.
February 2024 in “Epigenomes” Epigenetic mechanisms control skin development by regulating gene expression.
51 citations
,
August 2013 in “The Journal of experimental medicine/The journal of experimental medicine” Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
14 citations
,
May 2017 in “InTech eBooks” Hair is important for protection, social interaction, and temperature control, and is made of a growth cycle-influenced follicle and a complex shaft.
5 citations
,
May 2021 in “EMBO journal” Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
February 2024 in “International journal of molecular sciences” UV exposure reduced hair shine in mice, but minoxidil helped restore it.
426 citations
,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
143 citations
,
May 2017 in “Nature cell biology” Wounded skin cells can revert to stem cells and help heal.
42 citations
,
June 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” PAI-2 helps in the maturation and protection of hair and nail cells.
10 citations
,
June 2021 in “EMBO reports” When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.
7 citations
,
December 2021 in “Pharmaceutics” 3 citations
,
October 2023 in “Cosmetics” Healthy lifestyle changes can significantly improve skin health as you age.
September 2023 in “Animals” Hair follicle development in cashmere goats involves dynamic changes in proteins and metabolites, with key roles for oxytocin, MAPK, and Ca2+ pathways.
60 citations
,
December 2013 in “Development” Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.
1 citations
,
July 2023 in “International journal of biological macromolecules” Human hair proteins can help blood clot when mixed in equal parts.
42 citations
,
January 2017 in “Genes” The gene KAP22-1 affects wool yield and fiber shape in sheep.
27 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.
53 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” KAP genes show significant genetic variability, but its impact on hair traits is unclear.
8 citations
,
March 2004 in “Mammalian genome” KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.
7 citations
,
July 2019 in “Animals” The KRTAP21-1 gene affects wool yield and can help improve wool production.
119 citations
,
December 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
1 citations
,
May 2023 in “Journal of molecular evolution” Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.
December 2021 in “Molecular genetics and genomics” Cats with abnormal hair had DSG4 gene changes causing hair problems.
205 citations
,
May 2005 in “Journal of Investigative Dermatology” Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.
36 citations
,
November 2011 in “British Journal of Dermatology” White hair grows thicker and faster than black hair due to higher activity of growth-related genes and proteins.
6 citations
,
November 2021 in “Frontiers in immunology” STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” The mTurq2-Col4a1 mouse model shows that cells can divide while attached to stable basement membranes during development.
98 citations
,
October 2014 in “Trends in Molecular Medicine” Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.