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    Glossary Keratin 2

    protein providing structural strength to skin, hair, and nails

    Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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    Research 30 of 1000+

    1. The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family PloS one · 2016 · 14 citations
    2. The Mean Staple Length of Wool Fibre Is Associated with Variation in the Ovine Keratin-Associated Protein 21-2 Gene Genes · 2020 · 4 citations
    3. Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2 PloS one · 2015 · 22 citations
    4. Identification of the Keratin-Associated Protein 22-2 Gene in the Capra hircus and Association of Its Variation with Cashmere Traits Animals · 2023 · 1 citations
    5. Histopathological Analysis on keratin2-6 g Expression in Hair Mutant Mouse Hague Proceedings of The Japanese Society of Animal Models for Human Diseases · 2002
    6. Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits Genes · 2017 · 29 citations
    7. Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications Acta biomaterialia · 2015 · 75 citations
    8. Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation Biomedicines · 2021 · 16 citations
    9. Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice Journal of diabetes research · 2022 · 6 citations
    10. ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation BioMed Research International · 2020 · 2 citations
    11. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    12. 260 Anti-OX40 monoclonal antibody IMG-007 exhibited clinical activity of hair regrowth, suppressed scalp inflammatory biomarkers in patients with severe alopecia areata in a Ph1b/2a study Journal of Investigative Dermatology · 2025
    13. 269 Down-regulatory role of cholecystokinin on psoriatic epidermal inflammation Journal of Investigative Dermatology · 2017
    14. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin International journal of molecular sciences · 2023 · 1 citations
    15. The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics Animals · 2022 · 1 citations
    16. Current Genetics in Hair Diseases InTech eBooks · 2013 · 1 citations
    17. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    18. Effects Of Keratin-Gelatin And Basic Fibroblast Growth Factor-Gelatin Composite Film On Open Wound Healing In Dogs And Cats Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · 2007
    19. Identification and sequence analysis of the keratin-associated protein 24‐1 (KAP24-1) gene homologue in sheep Gene · 2012 · 51 citations
    20. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    21. Polymorphism of Keratin Gene KRT71 and Its Relationship with Wool Properties in Gansu Alpine Fine-Wool Sheep Animals · 2025
    22. Wool fiber curvature is correlated with abundance of K38 and specific keratin‐associated proteins Proteins · 2021 · 3 citations
    23. A Homozygous Missense Variant in K25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies 2022 · 2 citations
    24. Repeatable Perming via Thiol–Michael Click Reaction: Using Amide Derived from Maleic Acid and Cystine Molecules · 2026
    25. Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages Journal of Developmental Biology · 2025
    26. Crosstalk between vimentin and keratins in viral infection: Implications across the viral life cycle Virulence · 2026
    27. Clinical and Histologic Features of 64 Cases of Steatocystoma Multiplex The Journal of Dermatology · 2002 · 84 citations
    28. Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient Annals of Dermatology · 2017 · 9 citations
    29. Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin International journal of molecular sciences · 2019 · 4 citations
    30. Development and optimization of biotinoyl tripeptide-1 loaded solid lipid nanoparticles for protection against heat induced hair damage DergiPark (Istanbul University) · 2026