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    Glossary Keratin 1

    protein providing structural support in skin cells

    Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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    1. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage Journal of Cell Science · 1996 · 441 citations
    2. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    3. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development The Journal of Cell Biology · 1998 · 318 citations
    4. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins. Journal of Investigative Dermatology · 1989 · 238 citations
    5. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    6. Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2 British Journal of Dermatology · 1998 · 175 citations
    7. Keratin 17 modulates hair follicle cycling in a TN<i>Fα</i>-dependent fashion Genes & Development · 2006 · 169 citations
    8. Keratin 17 null mice exhibit age- and strain-dependent alopecia Genes & Development · 2002 · 122 citations
    9. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    10. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    11. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    12. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000 · 88 citations
    13. Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle Journal of Investigative Dermatology · 2002 · 87 citations
    14. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998 · 79 citations
    15. Keratin 17 Gene Expression during the Murine Hair Cycle Journal of Investigative Dermatology · 1997 · 70 citations
    16. Keratin 17 in disease pathogenesis: from cancer to dermatoses Journal of pathology · 2018 · 62 citations
    17. Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005 · 58 citations
    18. Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin. PubMed · 1999 · 54 citations
    19. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    20. The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties Journal of Biological Chemistry · 1998 · 46 citations
    21. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse Molecular Carcinogenesis · 2012 · 44 citations
    22. An unexpected role for keratin 10 end domains in susceptibility to skin cancer Journal of Cell Science · 2006 · 43 citations
    23. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    24. Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 1991 · 38 citations
    25. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    26. Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling PloS one · 2012 · 35 citations
    27. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. PubMed · 1994 · 33 citations
    28. cDNA Cloning, Expression, and Assembly Characteristics of Mouse Keratin 16 Journal of Biological Chemistry · 1998 · 32 citations
    29. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    30. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion 2011 · 30 citations