October 2023 in “Acta Medica Nicomedia” In this study, hirsutism negatively affected quality of life in Turkish patients, as measured by the Dermatology Life Quality Index, although no significant relationship was observed between the severity of hirsutism and quality of life scores.
1 citations
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September 2012 in “TURKDERM” In this study, alopecia areata patients reported higher anxiety, depression, and lower quality of life compared to those with androgenetic alopecia and healthy controls.
In this study conducted among high school students in rural Eskişehir, Turkey, alopecia prevalence was 37.4% and was associated with factors such as oily scalp and irregular menstruation, negatively affecting quality of life.
March 2026 in “Balkan Sağlık Bilimleri Dergisi” This review discusses the role of nurse navigators in managing polycystic ovary syndrome, highlighting their support in symptom management, lifestyle changes, psychosocial care, and evidence-based practices, but presents no new findings.
159 citations
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July 2014 in “Molecular pharmaceutics” This study found that MPEG-dihexPLA micelles significantly improved the skin deposition of tacrolimus compared to a marketed ointment, suggesting better targeted delivery with reduced systemic absorption.
116 citations
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December 2013 in “The Journal of Pediatrics” This study reported that treatment with gonadotropin-releasing hormone analogs and cross-sex hormones appears appropriate for carefully selected youth with gender dysphoria, but long-term safety needs further investigation.
109 citations
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March 2011 in “Journal of controlled release” This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.
109 citations
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October 2007 in “American Journal of Human Genetics” This study found that postnatal treatment with recombinant EDA normalized adult teeth, improved sweating, and restored normal lacrimation in dogs with XLHED, suggesting its potential as a treatment for the condition.
95 citations
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July 2010 in “Genes & development” In this study, the researchers reported that Notch/CSL signaling is crucial for hair follicle differentiation, with Wnt5a signaling and FoxN1 acting as mediators in mice.
58 citations
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February 2016 in “Scientific reports” This study found that dual inhibition of BACE1 and BACE2 in mice affects melanosome maturation and causes dose-dependent hair depigmentation without altering retinal morphology.
50 citations
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December 2005 in “European Journal of Immunology” This study found that a specific mutation in the mouse RXRalpha gene significantly impacts immune responses and causes hair loss and skin cysts.
44 citations
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August 2010 in “Journal of Investigative Dermatology” Alopecia areata seriously lowers quality of life, especially affecting self-image, mental health, and social life.
39 citations
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May 2006 in “Molecular Plant-Microbe Interactions” This study suggests that fusaric acid at nontoxic concentrations may activate signal transduction in plants which could aid in the plant-defense responses against Fusarium spp.
38 citations
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February 2006 in “British Journal of Clinical Pharmacology” This study found that combining data from different databases provided a more comprehensive estimate of serious adverse drug reactions in a French university hospital, highlighting the limitations of current ADR reporting methods.
36 citations
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October 2015 in “Journal of Cosmetic Dermatology” In this study, a new apple stem cell extract serum significantly improved signs of skin aging and enhanced cell metabolism in human senescent fibroblasts, showing visible effects after one week of use.
30 citations
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February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the orphan protein Plet-1 is expressed in specific keratinocytes of mouse hair follicles and may regulate keratinocyte interactions with inert tissues by affecting migration and adhesion.
29 citations
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November 2022 in “Nature Medicine” This study identified thousands of variant-metabolite associations in the human plasma metabolome, offering insights into the genetic bases of metabolism and potential adverse drug effects.
26 citations
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June 2020 in “The Journal of Allergy and Clinical Immunology In Practice” This case study highlights that even short-term use of hydroxychloroquine for COVID-19 can potentially lead to acute generalized exanthematous pustulosis as an adverse effect.
26 citations
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January 2014 in “ALTEX” This study investigated the modes of action of selected pesticides, suggesting that prochloraz and tebuconazole are linked to reproductive disorders via steroidogenesis disruption, while mancozeb involves inflammatory processes.
26 citations
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June 2011 in “International Journal of Pharmaceutics” This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.
24 citations
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September 2018 in “Lasers in Surgery and Medicine” This study shows that multiphoton microscopy can non-invasively distinguish between scarring and non-scarring alopecia by identifying certain morphological features, but further research is needed to confirm its clinical utility.
24 citations
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May 2015 in “Molecular and clinical oncology” In this study, both honey and bee pollen may alleviate menopausal symptoms in breast cancer patients on antihormonal treatment, with no significant difference between the two.
23 citations
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September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” In this mouse study, NF-κB was shown to play a role in hair follicle cycling and morphogenesis, with specific activity patterns differing by hair type and involving noncanonical signaling for zigzag hair bending.
15 citations
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December 2015 in “PLoS ONE” This study found that human adult dermal fibroblasts can express markers typically associated with neural cells, suggesting potential pitfalls in relying on immunophenotyping alone for cell identity verification.
15 citations
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February 2014 in “Journal of Investigative Dermatology” NF-κB activity is crucial for keeping hair in the growth phase.
14 citations
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May 2022 in “Stem cell reports” This study reported that human induced pluripotent stem cell-derived skin organoids, used to model epidermolysis bullosa, have an epidermal-dermal junction largely lacking type VII collagen, which is important for skin structure.
14 citations
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September 2021 in “Journal of Cosmetic Dermatology” This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.
13 citations
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February 2020 in “Journal of the American Academy of Dermatology” This study found that both oral tranexamic acid and microneedling improve melasma treatment outcomes when added to standard therapy, with microneedling showing a more sustained remission.
11 citations
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October 2020 in “Plant biotechnology journal” This study found that manipulating SIMK expression in alfalfa affects root hair growth, infection thread and nodule formation, and overall plant biomass, highlighting its potential biotechnological applications.
10 citations
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July 2022 in “Dermatology and Therapy” This review discusses the pathogenesis of melasma, including genetic, environmental, and hormonal factors, and highlights potential avenues for new treatments and preventive strategies, but reports no new experimental findings.