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GlossaryKeratin-Associated Proteins (KAP)

bind to keratin fibers, strengthening hair and nails

Keratin-Associated Proteins (KAPs) are a group of proteins that bind to keratin fibers, which are the structural components of hair, nails, and the outer layer of skin. They play a crucial role in the formation and strength of these keratin structures by cross-linking with keratin, thereby enhancing the rigidity and resilience of hair and other keratinized tissues.

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research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1

100 citations, December 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations, January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Human KAP Genes: Only Half of It? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes

53 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

KAP genes show significant genetic variability, but its impact on hair traits is unclear.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure

51 citations, January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.

research Characterization and Expression Analysis of KAP7.1 and KAP8.2 Genes in Liaoning New-Breeding Cashmere Goat Hair Follicles

48 citations, February 2010 in “Molecular biology reports”

KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.

research Polymorphisms in the Human High Sulfur Hair Keratin-Associated Protein 1, KAP1, Gene Family

48 citations, November 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Genetic variations in hair keratin proteins exist but don't significantly affect hair structure.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations, January 2017 in “Genes”

The gene KAP22-1 affects wool yield and fiber shape in sheep.

research Size Polymorphisms in the Human Ultrahigh Sulfur Hair Keratin-Associated Protein 4, KAP4, Gene Family

27 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.

research The Sheep KAP8-2 Gene, A New KAP8 Family Member That Is Absent In Humans

25 citations, September 2014 in “SpringerPlus”

Sheep have a unique gene, KAP8-2, that humans don't have, which may affect wool properties.

research Expression Analysis of KAP9.2 and Hoxc13 Genes During Different Cashmere Growth Stages by qRT-PCR Method

9 citations, June 2014 in “Molecular biology reports”

KAP9.2 and Hoxc13 genes are important for cashmere growth and vary in activity during different stages.

research Kaposi Varicelliform Eruption in a 26-Year-Old Man with Pemphigus Vulgaris

9 citations, January 2015 in “Indian Dermatology Online Journal”

Early diagnosis and treatment of Kaposi varicelliform eruption are crucial to prevent severe complications.

research Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

8 citations, March 2004 in “Mammalian genome”

KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.

research Runx1 Transcription Factor Is Involved in the Regulation of KAP5 Gene Expression in Human Hair Follicles

6 citations, January 2006 in “Journal of dermatological science”

Runx1 helps control the KAP5 gene in human hair follicles.

research Immunohistochemical Analysis of Procathepsin L and Cathepsin B in Cutaneous Kaposi's Sarcoma

6 citations, February 1997 in “International Journal of Dermatology”

Kaposi's sarcoma lesions might originate from benign tissue changes.

research A Rare Complication of Follicular Hair Unit Extraction: Kaposi’s Varicelliform Eruption

4 citations, January 2016 in “Dermatology practical & conceptual”

A man developed a rare skin condition after a hair transplant surgery.

research Kaposi Varicelliform Eruption in a Patient with Pemphigus Vulgaris: A Case Report and Review of the Literature

1 citations, December 2020 in “Case reports in dermatological medicine”

A patient with pemphigus vulgaris improved significantly after treatment for an additional viral skin infection.

research Biocompatibility Of Kaps-Depleted Residual Hair

May 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

KAP-depleted hair causes less immune response and is more biocompatible for implants.

research Effects of Different Concentrations of Androgens on KAP24.1 Gene Expression in Hetian Sheep and Karakul Sheep

June 2023 in “Gene”

Different androgen concentrations affect wool-related gene expression differently in Hetian and Karakul sheep breeds.

research Tinea Capitis in Two Siblings

April 2021 in “Cermin Dunia Kedokteran”

Two siblings with tinea capitis improved after treatment with ketoconazole.

research Identification of the KAP27-1 Gene in Sheep and Its Effect on Wool Traits

July 2022 in “New Zealand journal of agricultural research”

The KRTAP27-1 gene variations in sheep may affect wool length and weight.

research Downregulation of Nuclear Factor-KappaB Activation in Human Keratinocytes by Melanogenesis Inhibitors

May 2004 in “International Journal of Cosmetic Science”

Melanogenesis inhibitors like kojic acid and niacinamide can reduce inflammation and pigment production in skin cells.

research Cutaneous Manifestations of HIV Infection Other Than Kaposi's Sarcoma: Clinical and Histologic Aspects

54 citations, June 1990 in “Journal of The American Academy of Dermatology”

HIV can cause various severe or unusual skin conditions that help indicate the presence and stage of the disease.

research Quality of Life in Children with Tinea Capitis

November 2023 in “Cermin Dunia Kedokteran”

Tinea capitis can affect mental health, but treatment improves both health and well-being.

research 9-cis-Retinoic Acid Capsules in the Treatment of AIDS-Related Kaposi Sarcoma

52 citations, February 2003 in “Archives of dermatology”

9-cis-retinoic acid showed some effectiveness in treating AIDS-related Kaposi sarcoma but had significant side effects at higher doses.

research Development and Effectiveness Testing of Hair Tonic Formulation with Pea Extract (Pisum sativum L.) for Hair Loss and Baldness

January 2019 in “Prosiding Program Kreativitas Mahasiswa”

A 15% pea extract hair tonic effectively promotes hair growth and combats hair loss.