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Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Puberty often causes skin issues like acne and excessive sweating, and treatments require patience as results may vary.

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

Human stem cells were turned into cells similar to those that help grow hair and showed potential for hair follicle formation.

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

Inositol and arginine solutions improve hair follicle health and turnover.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

Woman has discoid lupus, frontal fibrosing, and androgenetic alopecia.

Psoriasis skin changes are complex and might need several biopsies for a clear diagnosis.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Keratin mutations cause skin diseases and could lead to new treatments.

Using special RNA to target a mutant gene fixed hair problems in mice.

Biodegradable polymers can improve cannabinoid delivery but need more clinical trials.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Using neurohormones to control keratin can lead to new skin disease treatments.

Histone modification is key in treating chronic inflammatory skin diseases.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.

Loss of keratin K2 causes skin problems and inflammation.