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This review discusses how research on keratin biology has enhanced the understanding of epidermolysis bullosa simplex and indicates potential new therapeutic approaches, but it presents no new experimental results.

Phospholipase Cδ1 is crucial for normal skin and hair development.

This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

Estrogen receptor α controls hair growth cycles and skin thickness in male mice.

HDAC1 is crucial for skin development and preventing tumors.

This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.

This study found that inactivating CerS4 in mice led to hair follicle stem cell exhaustion and hair loss, indicating its role in regulating hair regeneration through ceramide composition and signaling pathways.

The Dfl mutation in mice causes poor sebaceous gland function and complete hair loss.

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.

In this study, researchers found that contrary to expectations, keratin 10 domains did not reduce cell proliferation and instead increased tumor development in genetically modified mice.

This study found that Wnt7a-containing conditioned medium from UC-MSCs can accelerate wound healing and promote hair follicle regeneration by enhancing specific cellular functions in the wound microenvironment.

In vitro skin models are improving but still need more innovation to fully replicate human skin.

This study found that the unique functions of keratin 16 are likely determined by its tail domain, challenging the previous hypothesis about the role of the helix 1B subdomain.

In this study, the researchers reported extensive gene loss and high pseudogenization rates of α-keratin genes in cetaceans compared to terrestrial mammals, likely linked to hair loss and aquatic adaptations.

This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.

This study found that mice with a mutation in the Zdhhc13 gene exhibited increased susceptibility to skin cancer, highlighting a potential protective role of palmitoyl acyltransferase in skin carcinogenesis.

This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.

This study suggests that pilomatricoma can differentiate towards various hair follicle structures, including hair matrix, hair cortex, follicular infundibulum, outer root sheath, and hair bulge.

This study found that ferulic acid promotes wound healing by inhibiting β-catenin in keratinocytes and activating Nrf2 to reduce inflammation at the wound edge.

This study found that overexpressing the 14-3-3σ protein in transgenic mice reduced keratinocyte proliferation and migration, leading to thinner epidermis and fewer hair follicles due to IGF-1 pathway inhibition.

This study demonstrated that the tracheal xenotransplant procedure is an effective technique for assessing the invasiveness of epidermal keratinocytes and studying factors affecting hair follicle formation.

This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.

This article discusses the expression and potential new roles of innate immunity genes in CD49f(+) /CD34(+) hair follicle stem cells, but reports no new experimental results.

This study found that Hairless (HR) and putrescine form a negative regulatory network that impacts epidermal homeostasis and hair follicle cycling, linked to the MYC superfamily's regulation of ODC expression.

This review reports that the unique tunnel structures in advanced hidradenitis suppurativa impair quality of life and resist biological therapy, with their formation involving complex cellular and molecular interactions, including microbial dysbiosis, all contributing to ongoing inflammation and scarring.

This study observed that areola formation in mice requires exposure to pregnancy hormones and mechanical strain, beyond individual stimuli like hormonal milieu or strain alone.

This study investigated how 2D and 3D cell culturing methods influence hair follicle morphogenesis, finding that 3D cultures responded more expectedly to minoxidil while 2D cultures reacted better to DHT treatment, challenging the assumption that 3D cultures are always superior.

In this study, researchers found that disrupting desmoglein 3 signaling in a mouse model of pemphigus vulgaris activates normally quiescent hair follicle stem cells, compromising their multipotency but prompting a regenerative response that restores stem cell function and structures.

In this study, researchers found that retinoic acid is crucial for hair follicle stem cell function and tissue regeneration by resolving lineage plasticity, with potential therapeutic implications for hair growth, wound healing, and cancer.