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This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.

The researchers reported that stress-induced keratins in human skin are expressed at lower levels than those in healthy skin and are co-regulated with genes involved in differentiation, inflammation, and immunity, rather than replacing keratins of normal differentiation or indicating cell proliferation.

This study found that overexpression of betacellulin in transgenic mice delayed hair follicle morphogenesis and cycling, increased keratinocyte proliferation, and enhanced wound angiogenesis without affecting wound healing strength.

Human nails contain both skin and hair keratins, each needing different extraction methods.

This study found that a newly identified gene, mK17n, may explain the lack of nail issues in mK17 null mice by compensating for mK17's function in the nail bed.

This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.

This study observed that epidermal-specific deletion of aPKCλ in mice disrupts hair follicle stem cell quiescence, leading to altered hair follicle cycling and skin anomalies.

This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.

S100A8 and S100A9 proteins help form hair shafts during growth.

This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.

This study found that Stat3 removal in keratinocytes of mice impairs healing and disrupts the normal hair cycle, leading to skin ulcers and hair loss as they age.

This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.

This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.

This study found that the promoter region of the sheep KRTAP11-1 gene drives specific transcriptional activity in wool follicles, suggesting it may regulate hair keratinocyte specificity.

This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.

This study found that the anti-apoptotic Bcl-2 protein plays a crucial role in maintaining hair follicle stem cell function and influences tissue regeneration and tumor formation in mice.

This comprehensive review suggests that CD44 signaling plays a significant role in post-natal skin wound healing and scar formation, with potential for therapeutic approaches targeting CD44 to shift from fibrotic scarring towards regenerative healing, including wound regeneration and hair neogenesis.

In this study, researchers found that a subset of mammary cells with active Wnt signaling in mice does not develop tumors upon ErbB2 activation and instead undergoes apoptosis, potentially protecting against carcinogenesis.

This study found that intradermal injection of Secreted Frizzled-related Protein 4 inhibits, but does not block, hair follicle regeneration in mice, suggesting potential therapeutic applications for hair follicle regeneration disorders.

This study suggests that vitamin A may inhibit hair follicle stem cells during refractory telogen in a dose-dependent manner, based on retinyl ester levels and vitamin A metabolism protein localization in mice.

This study identified a recurrent mutation in the endothelin receptor type A associated with mandibulofacial dysostosis with alopecia, and proposed a mechanism involving increased ligand affinity due to structural changes.

This review examines the role of cannabinoid compounds in treating various skin conditions and suggests their potential as systemic and topical therapies, but it reports no new experimental results.

This review article analyzes the role of the WNT signaling pathway in skin development, wound healing, and mechanical stretching, emphasizing its importance in understanding and potentially advancing treatments for skin-related diseases.

This study found that ablating cyclin D3 in a Ras-dependent skin carcinogenesis model increased apoptosis in hair follicles, reducing papilloma development but potentially facilitating malignant progression when CDK6 is overexpressed.

This review discusses the genetic origins of autosomal recessive woolly hair with hypotrichosis and reports no clinical results; it highlights the link to homozygous variants in the K25 keratin gene.

This article highlights that while cannabinoids show potential for treating various skin conditions, current evidence is largely preclinical, with a need for comprehensive clinical trials to confirm these promising effects.

This review explores the potential of exosomes, which contain substances that may stimulate hair follicle activity, as a new therapeutic strategy for alopecia, and discusses their possible benefits and risks based on current knowledge of microRNAs and intracellular signaling in hair follicle morphogenesis.

This review discusses the potential topical benefits of cannabidiol in dermatology and cosmetics, highlighting its diverse effects and therapeutic roles but reports no new clinical results, emphasizing the need for further research.

This review explores the mechanisms, current products, challenges, and innovative approaches related to cosmetics for hair loss prevention and growth promotion, emphasizing the need for multidisciplinary cooperation to enhance product development and market success.

This study found that toll-like receptor 9 plays a previously unrecognized role in sensing skin injury and influencing tissue repair and regeneration in adult mice by modulating γδT cell migration.