Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that treatment with ritlecitinib led to significant scalp hair regrowth in patients with alopecia areata at Weeks 24 and 48, with higher response rates observed in those receiving 50 mg compared to 30 mg doses.

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.

Stat3 helps skin heal but can also cause skin diseases if overactive.

This study found that Rac1 is crucial for maintaining the integrity of hair follicle structure but is not needed for skin epidermis maintenance in mice.

This study found that differentiated cells of the corneal epithelium can be converted to hair and interfollicular epidermis through a multistep process involving dermal developmental signals.

This study reports the cloning and expression details of two new human type II keratins, K6irs3 and K6irs4, in the hair follicle's inner root sheath, suggesting a distinct functional role related to hair structure.

Fgfr2b helps maintain healthy skin and prevent cancer.

This study found that the K19 promoter is active in certain gastrointestinal cancer cells and its activity is influenced by the interaction between GKLF and Sp1 transcription factors.

This study describes the expression patterns of type I inner root sheath keratin proteins K25–K28 in human hair follicles, highlighting their distinct distribution within different layers.

In this study, transgenic mice overexpressing the glucocorticoid receptor in certain epithelia showed skin development abnormalities resembling ectodermal dysplasia and exhibited reduced inflammatory responses.

This review discusses the role of keratins in providing mechanical resilience to epithelial tissues and highlights recent therapeutic approaches for keratin diseases, but reports no new experimental findings.

In this study, K19-lacZ transgenic mice exhibited epithelial-specific reporter gene expression in tissues such as the pancreas and stomach, suggesting the K19 promoter is a valuable tool for studying epithelial cell biology.

HDAC1 is crucial for skin development and preventing tumors.

This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.

This study reports that sebaceous glands can regenerate after injury through stem cell plasticity, with hair-follicle-derived stem cells replacing sebaceous gland progenitors and playing a crucial role in the regeneration process, which is dependent on FGFR2 signaling and aided by hair growth induction.

This study found that K15 is variably expressed in sheep and mouse hair follicles, with specific patterns suggesting a role in the early stages of keratinocyte differentiation.

In this study, researchers observed that the sebaceous gland niche in mice allows for Wnt-induced hair follicle differentiation, unlike the non-permissive bulge.

This study presents the first detailed 3D models of the complete K1/K10 keratin dimer and identifies structural features and interactions that may inform understanding of keratin filament assembly.

This study found that EGFR-targeted cancer therapy can cause skin toxicities by disrupting epidermal signaling, allowing microbiota invasion and inflammation, but identified a potential treatment approach using FGF7 or SOS expression to restore barrier integrity.

This study shows for the first time that onychomatricoma can recapitulate the entire nail unit with differentiation toward the nail bed and isthmus, identifying new histopathological and immunohistochemical features.

This review summarizes recent findings on keratins 6, 16, and 17, highlighting their role in keratinocyte behavior and nuclear functions, and discusses their potential as biomarkers for various skin pathologies, including damage, inflammation, and cancer, rather than in healthy skin.

In this study, N-WASP deficiency in mouse skin was found to cause severe alopecia and disrupt hair follicle cycling by 5 months, highlighting its critical role in skin function and Wnt signaling.

This study found that Bcl-xL deficiency in mice increased apoptosis and resistance to skin tumor development, highlighting Bcl-xL's role in early skin carcinogenesis through anti-apoptotic functions.

This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.

In this study, researchers identified a highly reactive, isozyme-specific sequence for TGase 3, contributing to understanding its distinct functional role and activity distribution in the mouse epidermis.

This study reported that high ornithine decarboxylase expression and decreased keratin K1 and K10 expression may serve as useful markers for early stages of tumor development in mouse skin.

This study found that transgenic mice overexpressing human ATF3 showed hyperplastic and dysplastic changes in epithelial tissues, with a high incidence of oral cancer, suggesting potential oncogenic properties of ATF3.

This study found that the HS III element in the K14 gene's regulatory sequence promotes gene expression in inner root sheath keratinocytes, highlighting cooperative interactions in keratinocyte-specific gene regulation.

In this study, researchers found that hair follicle stem cells activate an immune-modulatory program during wound healing, promoting Treg cell expansion and aiding skin repair, while deleting certain immune components impaired healing and increased inflammation in a mouse model.

Fibroblasts from healthy donors can prevent changes seen in recessive epidermolysis bullosa simplex.