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Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Scientists found new, better-working inhibitors for a hormone-related enzyme.

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Finasteride may help prevent chronic bacterial prostatitis, with better results when combined with antibiotics.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

Tofacitinib therapy can effectively regrow eyebrows and eyelashes in some alopecia areata patients.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Certain cells around hair follicles help improve skin regeneration for potential use in skin grafts.

A patient with Ehlers-Danlos Syndrome improved after treatment for fat malabsorption and essential fatty acid deficiency.

People with obstructive sleep apnea are more likely to get herpes zoster, but nightmares don't affect the risk.

LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.

Zebrafish with mutations similar to human Cantú Syndrome have heart cells with altered channel properties, making them a good model to study the condition.

No current patient-reported outcome measure fully meets FDA requirements for alopecia treatments.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Spironolactone treatment increases the amount of testosterone available in the body.

Apoptosis is essential for human skin development and forming a functional epidermis.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

PGD2 stops hair growth and is higher in bald men with AGA.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Androgens, like testosterone, are crucial for early testicular descent in rats.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

K6hf is a unique protein found only in a specific layer of hair follicles.