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The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Targeting colon cancer stem cells might lead to better treatment results.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Alopecia areata, a common autoimmune hair loss condition, often runs in families.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

Dermoscopy helps diagnose and manage alopecia areata by showing specific hair changes.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Biotinidase deficiency has various symptoms and can be treated with biotin supplements.

The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Dermatoscopy and videodermatoscopy are useful for diagnosing and monitoring various skin, hair, and nail conditions.

Too much androgen can cause hair loss; finasteride may help.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Male pattern baldness involves hormones and cell signals affecting hair growth.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.