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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The Rotterdam Study aims to understand various diseases in older adults.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Hair analysis can detect cocaine use but doesn't accurately show the amount or timing of use.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Some drugs may reduce prostatitis symptoms short-term with few side effects.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Jaw wiring helps with weight loss but long-term habits are needed to keep it off.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.