90 citations
,
August 2006 in “British Journal of Dermatology” This paper describes the PRIDE syndrome associated with epidermal growth factor receptor inhibitors but reports no new clinical results.
88 citations
,
April 2012 in “Journal of Investigative Dermatology” This study suggests that TRPV3 may play a key role in dry skin-related itch, indicating potential for TRPV3 antagonists in treating pruritus resistant to histamine H1R antagonists.
61 citations
,
October 2011 in “Experimental dermatology” This review discusses the neurobiology and proposed mechanisms of scalp itch, but it does not report new clinical findings, highlighting the need for further research in this area.
27 citations
,
September 2009 in “British journal of nursing” This article discusses the role of emollient therapy in managing atopic eczema and other dry skin conditions and reports no new clinical findings.
15 citations
,
September 2018 in “Dermatologic therapy” In this study, the use of two emollients significantly reduced itching severity in individuals with xerotic eczema, starting 30 minutes post-application, and improved skin moisture and lipid content over 14 days, while demonstrating good tolerance with few adverse events.
9 citations
,
January 2013 in “Acta dermato-venereologica” The conclusion is that "trichoknesis" should be recognized as a separate condition from trichodynia, characterized by itching instead of pain.
7 citations
,
January 2012 in “International journal of trichology” Permanent hair removal with lasers may cure itchy black hair bristles on the back.
4 citations
,
January 2013 in “Acta dermato-venereologica” Some patients with Alopecia Areata experience itch due to immune cells and enzymes that cause itching.
1 citations
,
October 2019 This study found that skin-infiltrating neutrophils play a crucial role in triggering chronic itch in atopic dermatitis by promoting skin hyperinnervation and enhanced expression of itch signaling molecules in a mouse model.
1 citations
,
June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.
December 2025 in “Molecular Pain” This study identified that the MC-5-HT-HTR2A axis plays a role in chronic pruritus in a mouse model of SADBE-induced allergic contact dermatitis, suggesting potential for therapeutic targeting.
November 2025 in “Journal of Investigative Dermatology” Keloid fibroblasts cause itch and pain by releasing more histamine.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that structural changes in the TRPV3 channel are linked to severe skin conditions like Olmsted syndrome, with differences observed between heat-activated and resting states.
This study found that neutrophils are crucial for initiating chronic itch in atopic dermatitis and suggest that targeting neutrophils may help alleviate symptoms in this condition.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that keloids significantly impair quality of life, with pain and itch being major contributors to this impact, comparable to other chronic dermatologic conditions.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that mice lacking epidermal HSD11b1 had increased non-histaminergic itch and changes in skin nerve fibers, potentially linked to higher TSLP expression.
May 2011 in “Value in Health” This study found that the oral Janus kinase inhibitor CP-690,550 has a direct effect on reducing pruritus in patients with psoriasis, independent of clinician-assessed improvements in psoriasis severity.
This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
March 2005 in “Journal of The American Academy of Dermatology” Itch is a common symptom in patients with chronic venous insufficiency, often accompanied by burning and pain.
September 2024 in “Journal of the American Academy of Dermatology” Dermocosmetics significantly reduce itch and skin sensitivity in atopic dermatitis patients.
October 2014 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study identified a new subset of Ret-positive sensory neurons involved in itch perception, characterized by their unique expression profile and response to specific itch-inducing molecules.
July 2022 in “Dermatology practical & conceptual” This study found that a topical henna formulation may improve symptoms like itching, burning, and redness in patients with recessive dystrophic epidermolysis bullosa, but larger controlled studies are needed.
July 2018 in “Elsevier eBooks” This review discusses various causes and treatments of scalp pruritus, distinguishing between conditions with primary skin lesions and those without, but provides no new clinical results.
January 1978 in “Yukagaku” This study found that using a zinc pyrithione-containing hair rinse significantly reduced dandruff and itching, with effects linked to the amount of zinc pyrithione residue on the hair.
August 2024 in “Postgraduate Medical Journal” A rare skin reaction from cancer treatment was successfully managed with topical treatments and antihistamines.
December 2020 in “The Journal of Family Practice” This report describes an 11-year-old boy in Panama who visited a village health center due to scalp itching and subtle hair loss, previously treated for head lice, with no hair pulling reported.
About 17% of people in France have dandruff, and those with dandruff are more likely to have sensitive and itchy scalps.
This article reviews the complex causes of scalp pruritus and emphasizes the importance of thorough diagnosis, though some cases may lack a clear cause and rely on empirical treatment to alleviate symptoms.
28 citations
,
November 2017 in “Skin appendage disorders” This paper proposes a systematic approach to evaluating scalp itch using the SCALLP acronym and highlights the importance of classifying cases based on the presence of dermatological lesions and hair loss, but it reports no new clinical findings.
1 citations
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January 2025 in “Journal of Cosmetic Dermatology” Maintaining a balanced scalp microbiome can help reduce itchiness.