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Voriconazole can cause serious side effects, especially in long-term use.

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Finasteride helps reduce priapism in sickle cell anemia patients.

Skin problems are common and important signs of eating disorders and treating the eating disorder can improve these skin conditions.

Skin symptoms are important for diagnosing and managing juvenile-onset systemic lupus erythematosus and usually get better with treatment.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Adrenal disorders can cause lasting brain and behavior issues in children.

Oral JAK inhibitors are effective and safe for treating alopecia areata but may need ongoing use to keep results.

Eating disorders can cause skin problems that need treating the underlying condition for better health.

Type I interferons play a key role in the development of various skin diseases.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

The document concludes that treating tough skin disease in lupus involves sun protection, steroids, antimalarials, and various other therapies chosen based on individual risks and benefits.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

Rats had lasting erectile problems after stopping a certain medication.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

Deoxycholic acid is effective for reducing chin fat but can cause side effects and serious complications, so careful patient evaluation is needed.

Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Some treatments like methotrexate with prednisone might help juvenile morphea, but more research is needed to confirm.

The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.

Fat stem cells from diabetic mice can still help heal wounds.

Hydroxychloroquine showed some potential, but overall, the three drugs had limited success in treating lupus in dogs.

Dutasteride does not impair mental function in elderly men with enlarged prostate.