61 citations
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April 2009 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that irreversible and severe alopecia can occur following docetaxel or paclitaxel chemotherapy in breast cancer patients.
36 citations
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March 1989 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, the authors compared topical diphencyprone and tretinoin gel for treating alopecia totalis and universalis, but the abstract does not report any definitive clinical results.
30 citations
,
February 1977 in “Nature” This study found that high doses of irradiation can cause permanent hair loss in rats by destroying the epithelial elements of the hair follicle, while leaving the dermal papilla intact and capable of inducing new hair growth upon transplantation.
18 citations
,
February 2006 in “Genomics” A new genetic mutation in mice causes permanent hair loss and skin wrinkling.
11 citations
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June 2005 in “Stem Cells and Development” This study demonstrated that stem cells from the small intestine can differentiate into skin cells and reduce skin damage in irradiated mice, supporting the theory of stem cell plasticity.
9 citations
,
November 2012 in “Hepatology Research” This case study reports the first instance of irreversible alopecia universalis occurring during pegylated interferon-ribavirin therapy in a man with hepatitis C infection, without evidence of immunological or thyroid disorders.
8 citations
,
October 2020 in “International Journal of Environmental Research and Public Health” This study found that in women irradiated for tinea capitis as children, greater hair loss severity was associated with an increased risk of various mental health issues, particularly social anxiety.
3 citations
,
June 2023 in “European heart journal open” This study found that oligo-amenorrhea/menstrual irregularity in women is associated with an increased risk of overall cardiovascular disease, coronary heart disease, and myocardial infarction, while evidence linking hyperandrogenism or polycystic ovaries to cardiovascular disease remains mixed or unexplored.
1 citations
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April 1953 in “Acta Radiologica” Irradiating the whole central nervous system can lead to over 50% of patients with cerebellar medulloblastoma surviving three years.
January 2025 in “Interdisciplinary Research in Medical Sciences Specialty” This article proposes a novel approach to remodel the microenvironment of radiotherapy-induced skin defects, highlighting the lack of a standardized animal model as a barrier to progress in this field.
September 2024 in “Journal of the American Academy of Dermatology” Generic topical and transdermal systems usually cause minimal irritation or sensitization.
April 2024 in “Women s Health Reports” This study explored the clinical and biochemical hyperandrogenic status in adolescents with irregular menses to identify significant indicators of potential metabolic problems linked to PCOS.
January 2024 in “GeroScience” This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.
May 2023 in “Jurnal farmasi sains dan praktis” In this research on cinnamon and virgin coconut oil hair tonics, F2 and F3 demonstrated stable physical properties and mild irritation potential, while formula 1 remained non-irritating but less stable regarding pH and viscosity.
July 2022 in “International journal of medical science and clinical invention” In this case report, a 17-year-old girl with secondary amenorrhea was evaluated for PCOS, highlighting the importance of assessing abnormal menstrual patterns for underlying conditions, and suggesting that hormonal birth control and lifestyle changes can help manage symptoms.
August 2021 in “Pediatrics in review” This case study reports that a 16-year-old girl with hirsutism and menstrual irregularities was diagnosed with a benign steroid cell ovarian tumor, after high testosterone levels indicated a potential androgen-secreting source.
April 2021 in “Institutional Repositories DataBase (IRDB)” This study reported that high-intensity red LED irradiation increased osteogenic differentiation and mineralization of human bone marrow mesenchymal stem cells, potentially through Wnt/β-catenin pathway activation.
April 2020 in “Journal of the Endocrine Society” This case report emphasizes the importance of recognizing non-classic congenital adrenal hyperplasia as a cause of hyperandrogenism and the need for genetic counseling given potential familial implications.
In this animal study, treatment with Trachyspermum copticum seed extract significantly altered IL-1 and KGF/FGF-7 gene expression, improving dermatitis and hair growth in mice compared to controls and corticosteroids.
May 2016 in “International Society of Hair Restoration Surgery” This abstract describes a prior case of a patient who underwent a hair transplant to address alopecia resulting from radiation therapy; it contains no new findings.
October 2001 in “WORLD SCIENTIFIC eBooks” This compilation on contact and occupational dermatology in the Asia-Pacific region discusses various allergens and irritants without reporting new clinical findings.
120 citations
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October 2004 in “International journal of radiation oncology, biology, physics” In this study, the researchers established a dose–response relationship between the hair follicle dose during cranial irradiation and the development of permanent alopecia, with other factors showing limited correlation.
66 citations
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August 1999 in “The Journal of Clinical Endocrinology & Metabolism” This study found that menstrual irregularity is common in women with acromegaly, with high GH levels, estrogen deficiency, and larger tumors correlating with more severe irregularity.
32 citations
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November 2011 in “Reproductive Sciences” The study found that among young Brazilian women, the likelihood of metabolic syndrome in those with PCOS is strongly associated with BMI and the phenotype involving menstrual irregularity and hyperandrogenism.
30 citations
,
September 2017 in “Environmental health perspectives” This study found that potential exposure to Corexit™ dispersants during the Deepwater Horizon cleanup was associated with increased respiratory, dermal, and eye irritation symptoms among responders both during the cleanup and up to three years later.
17 citations
,
June 2017 in “Journal of pharmaceutical sciences” This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.
16 citations
,
November 2009 in “Experimental dermatology” This study found that ionizing irradiation significantly inhibits proliferation and induces apoptosis in human hair follicle keratinocytes, suggesting its potential as a preclinical assay system for testing radioprotectants.
15 citations
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February 2014 in “Toxicology Letters” This study found that osthole, a coumarin derivative, demonstrated significantly higher skin accumulation and potential skin irritation compared to coumarin, which showed negligible alterations in protein biomarkers.
12 citations
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April 1960 in “The anatomical record” This study found that X-irradiation affects the differentiation of hair follicles in mice, indicating possible impacts on hair growth.
11 citations
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January 1976 in “International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine” This study found that a single X-radiation treatment in rat skin reduced collagen concentration over multiple hair-cycles by diminishing the fibroblasts' capacity for proline hydroxylation, potentially contributing to delayed skin lesions.