12 citations
,
January 2016 in “Journal of clinical biochemistry and nutrition” In this study, combining deferasirox with sorafenib significantly reduced liver fibrosis and preneoplastic lesions in rats while also lessening adverse effects compared to sorafenib alone.
October 2025 in “Journal of Investigative Dermatology” This review highlights the critical role of iron in skin functions and suggests potential dermatologic therapies targeting the iron-skin axis.
245 citations
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January 2010 in “Blood” This study suggests that antihepcidin antibodies may effectively treat inflammatory anemia by manipulating iron metabolism, based on experiments conducted in mouse models and hHepc knock-in mice.
180 citations
,
October 2019 in “British journal of haematology” These guidelines provide updated recommendations for healthcare professionals on preventing, diagnosing, and treating iron deficiency in pregnant and postpartum women in the UK, acknowledging the lack of high-quality evidence for many current practices.
163 citations
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November 2003 in “Journal of Investigative Dermatology” This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.
79 citations
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January 2017 in “Dermatology practical & conceptual” This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.
70 citations
,
January 2015 in “Journal of Clinical and Diagnostic Research” This review discusses the various triggers and diagnostic challenges in determining the cause of telogen effluvium-related hair loss, without providing new clinical results.
67 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses telogen effluvium, a common type of hair loss, focusing on differentiation from other conditions and potential causes, but presents no new research findings.
47 citations
,
May 2012 in “Applied Water Science” In this study, contaminated drinking water in Dakahlyia governorate was linked to health issues like hair loss, renal failure, and liver cirrhosis, attributed to industrial and agricultural pollutants.
24 citations
,
June 2010 in “Clinics in Dermatology” This review discusses various potential adverse effects of common oral vitamin and mineral supplements used in dermatology and highlights lesser-known issues like hematologic and neurologic effects from zinc.
22 citations
,
June 2001 in “International Journal of Cosmetic Science” This review discusses the role of iron from cosmetic sources in skin nutrition and reports no clinical results, highlighting its significance for skin, hair, and nail health.
14 citations
,
January 2006 in “Journal of Investigative Dermatology” This study found that controlling transferrin receptor expression effectively regulates iron content in the epidermis and hair of transgenic mice.
10 citations
,
September 2023 in “Metabolites” This study reviews iron metabolism in the skin, highlighting how differentially expressed genes regulate iron recycling in the epidermis, and discusses changes in iron metabolism related to skin diseases.
9 citations
,
October 2010 in “Journal of the American Academy of Dermatology” Iron deficiency might cause hair loss, but better testing is needed.
8 citations
,
May 2021 in “Applied Materials Today” This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.
7 citations
,
January 2017 in “Journal of Clinical Biochemistry and Nutrition” This study found that vitamin D was positively associated with serum ferritin levels in Korean women without metabolic syndrome, but this association was not observed in those with metabolic syndrome.
5 citations
,
August 2018 in “International Journal of Dermatology” This study suggests obstructive sleep apnea may increase the risk of male-pattern baldness in men with a family history of hair loss, and links low serum transferrin saturation levels to both conditions.
4 citations
,
March 2019 in “IP Indian Journal of Clinical and Experimental Dermatology” This study observed an association between body iron levels and non-scarring diffuse hair loss in non-menopausal women.
3 citations
,
December 1956 in “PubMed”
2 citations
,
January 2012 in “Hair therapy & transplantation” This study found no significant link between iron metabolism, including serum ferritin and hemoglobin levels, and telogen effluvium in women under 40 years old.
1 citations
,
August 2023 in “Cutis” This review discusses the role of ferritin in iron homeostasis and its potential utility in diagnosing iron deficiency as a cause of hair loss, while noting that ferritin's impact on skin and hair disorders is not fully understood.
1 citations
,
May 2017 in “InTech eBooks” This article discusses telogen effluvium, emphasizing the importance of understanding its natural progression and highlights the need for a detailed patient evaluation but provides no new clinical results.
This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.
September 2025 in “Romanian Journal of Medical Practice” In this study of women with female pattern hair loss, iron deficiency was associated with the condition due to significantly lower serum ferritin and altered hematological indices compared to healthy controls, while no significant differences in serotonin levels or renal function were observed.
March 2024 in “International journal of molecular sciences” This study suggests that abnormal levels of zinc, copper, and iron in serum or hair may serve as auxiliary and prognostic tests for various skin diseases, though further research is necessary due to conflicting data.
This study developed a mathematical model using hair biomarkers (levels of Mg, K, Fe, Al, Cr) to noninvasively predict iron content in Hereford cattle muscle tissue, potentially improving livestock management and meat quality.
March 2024 in “Indian Journal of Dermatology” In this observational study, researchers found that women with telogen effluvium who had higher baseline ferritin levels or received higher doses and longer durations of iron supplementation reported greater satisfaction, suggesting that iron supplementation can improve patient satisfaction regardless of initial ferritin levels.
This study found that while iron depletion through phlebotomies is safe for women with functional ovarian hyperandrogenism, it does not improve their cardio-metabolic profile and may reduce non-enzymatic antioxidant capacity.
May 2022 in “Clinical Epigenetics” This study found that maternal early-pregnancy serum ferritin concentrations were associated with lower DNA methylation levels at specific CpG sites in cord blood, with some associations persisting into childhood.
January 2022 in “International journal of zoological investigations” In this study, the prevalence of PCOS was reported to be approximately 10% among urban college girls in Chennai, with increased testosterone and decreased progesterone levels observed.