8 citations
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July 2019 in “Pure and Applied Chemistry” This study identified natural compounds from Iris plants that showed potential as inhibitors of urease and carbonic anhydrase-II enzymes, suggesting their possible use in treating related disorders.
April 2025 in “International Journal of Molecular Sciences” In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.
October 2023 in “Applied sciences” In this study, Iris germanica L. rhizome-derived exosomes were found to reduce oxidative stress, enhance antioxidant enzyme transcription, and restore cellular function in human epidermal keratinocytes, suggesting potential protective effects against oxidative-stress-induced skin damage.
August 2024 in “Journal of Personalized Medicine” In this study using a rabbit model, higher incidences of intraoperative floppy iris syndrome were observed in animals given the α-blocker tamsulosin, suggesting a potential association with increased iris billowing during eye surgery.
January 2022 in “Essentials in ophthalmology” This review discusses risk factors for intraoperative floppy iris syndrome, emphasizing tamsulosin and other α1 blockers, and underscores the importance of preoperative screening to mitigate surgical complications, but it reports no new results.
49 citations
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December 2007 in “Journal of Cataract and Refractive Surgery” This case report suggests that oral finasteride, used for benign prostatic hyperplasia, may be associated with intraoperative floppy-iris syndrome during cataract surgery.
41 citations
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December 2008 in “Current Opinion in Ophthalmology” This review describes techniques to manage intraoperative floppy iris syndrome linked to alpha-1 blocker use in cataract surgery, highlighting the need for patient disclosure of medication use but reports no new clinical results.
29 citations
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May 2011 in “Journal of Cataract and Refractive Surgery” This case report suggests a possible association between long-term finasteride use for male pattern baldness and the development of cataracts and intraoperative floppy-iris syndrome in a patient.
28 citations
,
February 2020 in “Clinical Ophthalmology” This article discusses intraoperative floppy iris syndrome during cataract surgery and highlights the importance of awareness and preoperative documentation of its risk factors, emphasizing a multidisciplinary approach to management.
22 citations
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June 2011 in “Acta Ophthalmologica” This study found that current use of benzodiazepines, α1-blockers (like tamsulosin, alfuzosin, terazosin), finasteride, and possibly rivastigmine is associated with increased risk of intraoperative floppy iris syndrome in cataract surgery patients.
3 citations
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February 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review discusses the challenges of managing intraoperative floppy iris syndrome during cataract surgery and highlights the importance of preoperative risk assessment and multidisciplinary collaboration, reporting no new clinical results.
3 citations
,
October 2015 in “PubMed” This study found an increased risk of intraoperative iris billowing in rabbits treated with finasteride, similar to those treated with tamsulosin, suggesting further research in humans is needed.
October 2025 in “Cermin Dunia Kedokteran” This review outlines the strategies for managing TB-IRIS in HIV patients, emphasizing early detection, prevention, and appropriate treatment to reduce morbidity and mortality.
January 2018 in “Haydarpaşa Numune Hastanesi tıp dergisi” This study hypothesizes that the sulfonamide group in tamsulosin might contribute to its association with intraoperative floppy iris syndrome.
November 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found an IFIS incidence rate of 3.18% among cataract surgeries in a Chinese hospital and identified reserpine, clozapine, and post-panretinal photocoagulation as new risk factors.
January 2016 in “Yanwaishang zhiye yanbing zazhi” In this study, atropine and neosynephrine significantly reduced the incidence of intraoperative floppy iris syndrome during age-related cataract surgery in patients at high risk.
May 2022 in “International Journal of Trichology” 55 citations
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July 2016 in “Eye”
22 citations
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March 2018 in “International Ophthalmology” This study found that tamsulosin, finasteride use, and aging are significantly associated with increased risk of intraoperative floppy iris syndrome during cataract surgery, while doxazosin does not appear to pose this risk.
1 citations
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July 2022 in “Journal of Cataract and Refractive Surgery” This meta-analysis reports that male sex, hypertension, tamsulosin, finasteride, benzodiazepines, and antipsychotics are significantly associated with increased risk of developing intraoperative floppy-iris syndrome during cataract surgery.
August 2013 in “Acta Ophthalmologica” This study found that medications including benzodiazepines, quetiapine, and certain alpha-blockers, along with hypertension and short axial length, were independently associated with an increased risk of Intraoperative Floppy Iris Syndrome during cataract surgery.
39 citations
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April 2001 in “Journal of The American Academy of Dermatology” This article reviews the side effects of topical latanoprost therapy, particularly the hypertrichosis and pigmentation changes of eyelashes and nearby skin, and reports no new clinical results.
34 citations
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February 2018 in “Drug Design Development and Therapy” This source reports that bimatoprost, a medication approved for eyelash growth, has shown efficacy in treating eyebrow hypotrichosis, suggesting it as a noninvasive, effective, and well-tolerated option for enhancing eyebrow hair.
32 citations
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August 2016 in “Journal of the American Academy of Dermatology” This letter discusses congenital triangular alopecia (TTA), a non-scarring hair loss condition often seen in children, without reporting new clinical findings.
31 citations
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October 2012 in “Archives of ophthalmology” Laser hair reduction near the eyebrows can cause serious eye injuries even with safety measures.
19 citations
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April 1995 in “Clinical Genetics” This report describes two siblings with a new familial association of loose anagen syndrome and ocular coloboma, despite unaffected parents and no family history.
222 citations
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January 2014 in “International journal of reproductive medicine” This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.
71 citations
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January 2015 in “The Scientific World Journal” This review discusses the link between insulin resistance and skin conditions such as acanthosis nigricans and psoriasis, but provides no new clinical results.
34 citations
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January 2014 in “Indian Dermatology Online Journal” This study supports evaluating metabolic syndrome and insulin resistance in young males with advanced androgenic alopecia to potentially reduce future cardiovascular and type 2 diabetes risks.
14 citations
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September 2017 in “Clinics in Dermatology” This study highlights that lower testosterone in men and higher testosterone in women are linked to increased risks of metabolic syndrome and type 2 diabetes, with associated skin diseases indicating potential cardiovascular complications.