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This study found that culturing fibroblasts on stiffer substrates mimicking fibrotic wounds led to an aligned EDA fibronectin matrix with thinner fibers and decreased YAP activity, suggesting disrupted signaling that might be restored to promote regenerative wound repair.

This study found that irisin, a myokine, increases hair growth by activating the Wnt/β-catenin pathway, enhancing cell proliferation and hair shaft elongation in both human cell and mouse models.

This study identified a mutant in Arabidopsis with shorter root hairs due to early growth cessation, implicating the IRE gene in regulating root hair growth duration.

This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.

Isoginkgetin reduces inflammation in cells by blocking NF-κB activation.

This study suggests that icariin promotes hair follicle growth in mice by enhancing IGF-1 expression in dermal papilla cells.

This review synthesizes research on hederagenin's anticancer and anti-inflammatory potential, emphasizing chemical modifications to enhance its bioactivity, but reports no new experimental findings.

This review of 355 articles found that apigenin, a compound found in many plants and vegetables, is mainly researched for its anti-inflammatory, neuroprotective, and anti-cancer properties, with enhanced efficacy when combined with allopathic drugs.

This study suggests that apigenin may stimulate hair growth by downregulating TGF-ß1 gene expression in human epidermal keratinocytes and promoting hair follicle elongation in a rat hair follicle culture.

In this study, Iris germanica L. rhizome-derived exosomes were found to reduce oxidative stress, enhance antioxidant enzyme transcription, and restore cellular function in human epidermal keratinocytes, suggesting potential protective effects against oxidative-stress-induced skin damage.

This study found that torilin from Torilis japonica fruit extract inhibited 5 alpha-reductase in vitro more effectively than alpha-linolenic acid but less effectively than finasteride.

In this study, a newly designed protein degrader targeting androgen receptors showed promise in reversing hair regrowth inhibition in a mouse model of androgenetic alopecia, suggesting potential as a novel and safe treatment strategy.

In this study, EREG promoted hair growth by activating specific receptors in cell and animal models, indicating it may be a potential treatment for hair loss.

In this study, deleting the Igf1 receptor in specific skin cells of mice affected hair follicle cycling but not overall skin health, suggesting Igf1r's role in hair cycle regulation through Bmp-4 activation.

In this study, Ishige sinicola extract was observed to improve bone density and structure in an animal model of estrogen deficiency-induced osteoporosis, suggesting its potential as a therapeutic option for postmenopausal osteoporosis by inhibiting osteoclast formation without cytotoxic effects.

This study identified natural compounds from Iris plants that showed potential as inhibitors of urease and carbonic anhydrase-II enzymes, suggesting their possible use in treating related disorders.

This study found that EGF, IGF-Ⅰ, and IGF-Ⅰ R are extensively expressed in mink skin and hair follicles, suggesting these genes play crucial roles in their development.

This study found that Ishige sinicola extract increased hair growth and cell proliferation in cultured vibrissa follicles and mice, suggesting potential benefits for treating alopecia through β-catenin activation and 5α-reductase inhibition.

LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.

This study found that Naringenin and Hesperetin significantly increased the proliferation of hair-related cells and suggested potential as natural hair growth-promoting agents.

This study found that the humanin analogue HNG significantly promoted hair growth in vitro and in vivo by prolonging the anagen phase and inhibiting hair follicle cell apoptosis in mice.

In this study, red ginseng extract and its ginsenosides enhanced human hair follicle cell proliferation and countered dihydrotestosterone-induced suppression, suggesting potential to promote hair growth.

This study suggests that EREG, released from ORS cells, may promote hair growth by activating specific receptors and modulating ROS generation, offering a potential new treatment for hair loss.

In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.

This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.

Isoquercitrin helps hair grow by activating certain cell processes.

This study found that isoliensinine, a natural compound identified from a database, effectively prevented stress-induced hair greying in mice by blocking β-2 adrenergic receptors on melanocyte stem cells in hair follicles.

This study found that treating human dermal fibroblast cells with ginsenoside Rd increased the expression of mRNA associated with the dermal-epidermal junction, suggesting potential as an anti-aging cosmetic ingredient.