143 citations
,
May 2022 in “Pharmaceuticals” This review discusses alginate-based delivery systems for probiotics, highlighting recent advances, challenges, and future directions, but reports no new clinical findings.
140 citations
,
January 2021 in “Journal of the International Society of Sports Nutrition” This source reports that while creatine supplementation is popular for improving muscle mass and performance, questions about its efficacy and safety persist. An expert team is reviewing literature to address concerns like water retention, renal effects, and its benefits across different populations and uses.
135 citations
,
October 1997 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that trichohyalin is modified by peptidyl-arginine deiminase before being cross-linked by TGase 3, allowing the formation of rigid structures in hair follicle cells.
128 citations
,
February 2023 in “Molecules” This review article discusses recent progress in chitosan-based hemostatic hydrogels, highlighting their unique properties, such as biocompatibility and enhanced hemostatic performance, compared to traditional materials. The authors summarize their hemostatic mechanisms and future potential in improving emergency bleeding control.
125 citations
,
March 2017 in “Micromachines” This review highlights recent advancements in microfluidics for 3D tissue model generation and discusses its applications in tissue engineering and high-throughput drug screening without reporting new experimental results.
111 citations
,
April 2023 in “Ultrasonics Sonochemistry” This review discusses the extraction, purification, and biological activities of maidenhairtree polysaccharides, emphasizing the higher efficiency of ultrasound-assisted extraction, but it reports no new clinical results.
110 citations
,
April 2020 in “Advances in Wound Care” This review discusses recent advancements in nanotechnology-based treatments for chronic wound healing in diabetic models, noting that despite promising results, these innovations have yet to translate into widely available commercial products.
110 citations
,
September 2017 in “Molecules” This review discusses the phytochemistry, pharmacology, pharmacokinetics, and standardization of Forsythiae Fructus, detailing both unripe and ripe forms, but reports no new clinical results.
97 citations
,
December 2021 in “Cells” This review outlines key considerations for designing fluorescence microscopy experiments in cell biology, discussing the importance of hardware availability, suitability of biological models, and imaging agents to achieve high-resolution and informative images.
96 citations
,
September 2021 in “International Journal of Molecular Sciences” This review highlights recent advances in chitosan-based nanoparticles (CS NPs) for drug delivery, discussing their modifications, preparation methods, production with organic and inorganic materials, and their latest implementations in the field, emphasizing the role of CS NPs in improving drug transport and release properties.
91 citations
,
December 2000 in “The journal of cell biology/The Journal of cell biology” This study reports that expressed mouse type Ia and type IIa trichocyte keratins were successfully assembled into intermediate filaments in vitro, while also suggesting that disulfide bond cross linking enhances their stability.
90 citations
,
October 2023 in “Advanced Drug Delivery Reviews” This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.
86 citations
,
April 2009 in “Journal of anatomy” This paper reviews the evolution of skin appendages and keratin-associated proteins among amniotes, proposing a model for their genetic divergence without new experimental results.
80 citations
,
January 2020 in “Journal of Nanobiotechnology” This review highlights that incorporating nanomaterials into scaffolds can significantly enhance angiogenesis in tissue regeneration by simulating extracellular matrix structures and effectively delivering angiogenesis-related factors, offering promising designs for vascularization and therapeutic applications.
79 citations
,
December 2017 in “Cosmetics” This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.
78 citations
,
February 2024 in “ACS Omega” This study developed a bilayer material combining poly(vinyl alcohol) and bacterial cellulose with a gelatin-poly(vinyl alcohol) hydrogel, showing strong potential as a wound dressing due to its good antibacterial properties, cell viability, and sustained drug release.
76 citations
,
February 2024 in “International Journal of Molecular Sciences” This review discusses the growing importance of hydrogel scaffolds in skin wound healing, highlighting their unique properties and recent advancements in their use for treating difficult tissue damage, particularly within tissue engineering.
73 citations
,
February 2023 in “Polymers” This review discusses the unique properties, design, and fabrication of peptide hydrogels for biomedical applications, focusing on advances in drug delivery, gene therapy, and regenerative medicine; it reports no new clinical results.
69 citations
,
November 2023 in “Heliyon” This abstract discusses the importance of developing intelligent and multifunctional dressings with skin-like properties for real-time wound monitoring, highlighting their potential to improve wound management, prognostic evaluation, and the integration of health monitoring into clinical practice.
69 citations
,
January 2021 in “Journal of Biological Chemistry” This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.
61 citations
,
April 2023 in “Bioactive Materials” This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.
61 citations
,
June 2022 in “Journal of Controlled Release” This review discusses the advantages, applications, and current trends of dissolving microneedles for drug delivery across various therapeutic areas and reports no new clinical results.
57 citations
,
November 2024 in “Aggregate” This review article highlights recent advancements in smart hydrogels as promising solutions for diabetic wound management, emphasizing their ability to respond to wound environments and deliver targeted therapies, while addressing limitations of traditional dressings.
54 citations
,
June 2020 in “Pharmaceutics” This review discusses the advancements in using "soft" colloidal nanocarriers for delivering photosensitive agents and highlights their potential applications in treating diseases like cancer, but it reports no new clinical results.
51 citations
,
October 2024 in “Pharmaceutics” This review highlights the potential of permeation enhancers to improve the delivery of active ingredients across the skin, optimizing therapeutic outcomes despite challenges posed by individual variability and environmental factors, according to the authors' analysis of current understanding and applications in skincare and transdermal therapies.
51 citations
,
January 2014 in “International journal of trichology” This review examines the pH levels of various shampoos and reports no new clinical results, highlighting the potential importance of labeling pH values on shampoo packaging for hair and scalp health.
51 citations
,
September 2012 in “Biomacromolecules” This study found that disulfide bonds in keratin increase its strength and toughness, with some loss of α-helical structure under load, highlighting their role in trichocyte α-keratin's mechanical properties.
49 citations
,
November 2021 in “Annual review of pathology” This review discusses the regulatory roles of lysophospholipids like LPA and S1P in diseases such as fibrosis, neuropathic pain, and cancer, but reports no new clinical results.
48 citations
,
January 2024 in “Frontiers in Pharmacology” This paper reviews strategies to enhance the effectiveness of topical drug delivery by addressing skin barrier challenges, optimizing drug delivery systems, and personalizing treatment approaches, highlighting both current advancements and limitations in the field.
48 citations
,
December 2022 in “Biomolecules” This review discusses recent advancements in 3D bioprinting for skin regeneration and describes potential improvements for clinical applications, but it reports no new experimental results.