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      Androgenetic Alopecia: Update on Etiology, Pathophysiology, Diagnosis, and Treatment

      research Androgenetic Alopecia: update on Etiology, Pathophysiology, Diagnosis and Treatment

      March 2024 in “International journal of pharmaceutical sciences and drug research”
      In this review, the authors explored current and novel treatment options for androgenetic alopecia, noting both FDA-approved pharmacologic treatments like Minoxidil and Finasteride and various non-pharmacologic and surgical methods, including hair transplantation and scalp micro-pigmentation.
      Follicular Transport Route: Research Progress and Future Perspectives

      research Follicular transport route – Research progress and future perspectives

      211 citations , February 2009 in “European journal of pharmaceutics and biopharmaceutics”
      This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.
      Androgen Excess: Investigations and Management

      research Androgen excess: Investigations and management

      82 citations , May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”
      This article outlines the clinical features, evaluation, and treatment strategies for androgen excess in polycystic ovary syndrome, highlighting important diagnostic and management approaches but reporting no new research results.
      Hair Changes Caused by Aging

      research Hair Changes Caused by Aging

      September 2014 in “Springer eBooks”
      Aging causes hair to gray and thin, with the timing of graying varying by race, and factors like oxidative stress and genetics can lead to hair loss.
      Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

      research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

      1533 citations , October 2008 in “Endocrine reviews”
      This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
      Epithelial Stem Cells: Turning Over New Leaves

      research Epithelial Stem Cells: Turning over New Leaves

      508 citations , February 2007 in “Cell”
      This article reviews the biology of epithelial stem cells and their role in tissue self-renewal, maintenance, and regeneration, and it highlights the clinical implications of understanding their signaling pathways, but it presents no new clinical findings.
      Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions

      research Melatonin membrane receptors in peripheral tissues: Distribution and functions

      506 citations , January 2012 in “Molecular and Cellular Endocrinology”
      This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.
      Alopecia Areata Update

      research Alopecia areata update

      391 citations , January 2010 in “Journal of The American Academy of Dermatology”
      This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.
      Melatonin in the Skin: Synthesis, Metabolism, and Functions

      research Melatonin in the skin: synthesis, metabolism and functions

      252 citations , January 2008 in “Trends in Endocrinology and Metabolism”
      This review discusses the protective and stress-buffering roles of melatonin in skin functions and structures but does not present new clinical findings.
      Epithelial Stem Cells And Implications For Wound Repair

      research Epithelial stem cells and implications for wound repair

      156 citations , October 2012 in “Seminars in Cell & Developmental Biology”
      This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
      The Pathogenesis of Primary Cicatricial Alopecias

      research The Pathogenesis of Primary Cicatricial Alopecias

      150 citations , October 2010 in “The American Journal of Pathology”
      This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.
      Human Skin Stem Cells and the Aging Process

      research Human skin stem cells and the ageing process

      143 citations , September 2008 in “Experimental gerontology”
      This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
      Estrogens and the Skin

      research Estrogens and the skin

      137 citations , June 2005 in “Climacteric”
      This review indicates that estrogen loss during menopause significantly impacts skin health, while estrogen treatment may increase skin collagen, thickness, and elasticity, though effects on other skin characteristics are inconsistent.
      The Circadian Clock in Skin

      research The Circadian Clock in Skin

      127 citations , January 2015 in “Journal of Biological Rhythms”
      This review discusses the role of the circadian clock in skin functions such as cell proliferation and UV protection and reports no new results; the authors note its potential in studying immune regulation and seasonal behaviors.
      Isotretinoin Treatment of Acne and Related Disorders: An Update

      research Isotretinoin treatment of acne and related disorders: An update

      126 citations , October 1983 in “Journal of The American Academy of Dermatology”
      This report verifies isotretinoin's significant efficacy in treating severe acne over the past year in the U.S., highlighting the need for careful patient selection and monitoring due to potential side effects.
      From Causes of Aging to Death from COVID-19

      research From causes of aging to death from COVID-19

      122 citations , June 2020 in “Aging”
      This review discusses the hyperfunction theory of aging as a key factor in COVID-19 vulnerability, highlighting the potential of anti-aging interventions like rapamycin to reduce this risk.
      Dermal White Adipose Tissue: A New Component of the Thermogenic Response

      research Dermal white adipose tissue: a new component of the thermogenic response

      92 citations , September 2015 in “Journal of Lipid Research”
      This review discusses the roles of dermal white adipose tissue (dWAT) as an insulator, antibiotic, and regenerative tissue, highlighting its importance in systemic metabolism and immune function, but reports no new clinical results.
      Androgenetic Alopecia: An Update

      research Androgenetic alopecia: An update

      88 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”
      This article reviews recent advancements in understanding and treating androgenetic alopecia, focusing on new genetic insights, stem cell roles, and diagnostic tools, without reporting new clinical results.
      TNF Superfamily in Skin Appendage Development

      research TNF superfamily in skin appendage development

      86 citations , May 2008 in “Cytokine & growth factor reviews”
      This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.