52 citations
,
January 2003 in “Journal of Investigative Dermatology” This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.
40 citations
,
November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that different melanocyte subpopulations in hair follicles have varying patterns of apoptosis and survival during the catagen phase, which may inform models for modulating melanocyte behavior in vivo.
43 citations
,
December 2006 in “The American journal of pathology” This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.
2 citations
,
May 2001 in “Current problems in dermatology” The conclusion is that effectively treating hair disorders is difficult due to the complex factors affecting hair growth and more research is needed to improve treatments.
1 citations
,
January 2004 This review discusses epithelial-mesenchymal interactions in hair follicle development and their regulation by molecular signals, but reports no new results; the authors emphasize the need for further research to apply these findings clinically.
165 citations
,
December 2004 in “Differentiation” This review discusses the critical role of BMP signaling in the development and regulation of skin and hair follicles and notes that further research could aid therapeutic advances; it presents no new clinical results.
29 citations
,
April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study found that ICAM-1 expression in murine skin is developmentally regulated and crucial for skin and hair follicle remodeling beyond its recognized role in immune responses.
7 citations
,
January 1981 in “Springer eBooks” The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.
1 citations
,
August 1994 in “Journal of Cutaneous Pathology” This study found that matrix cells from normal hair follicles primarily had a 2C DNA content, while those in androgenetic alopecia showed a significant increase in cells with a higher DNA content.
3 citations
,
October 2019 in “CRC Press eBooks” This review discusses isotretinoin's effectiveness against severe acne vulgaris and its associated side effects, including teratogenicity and hair loss, but it reports no new experimental results.
24 citations
,
January 2003 in “Journal of Investigative Dermatology” In this study, a synthetic antagonist of the p75 neurotrophin receptor was found to significantly inhibit hair follicle regression in murine skin cultures, suggesting a potential role in treating hair disorders characterized by premature catagen entry.
47 citations
,
July 1997 in “British Journal of Dermatology” This research observed that during the catagen phase, the inner root sheath of hair follicles becomes an early target, highlighting its potential role in maintaining hair follicle homeostasis.
23 citations
,
July 1997 in “British Journal of Dermatology” This study suggests that the inner root sheath plays a significant role in maintaining hair follicle homeostasis during the catagen phase's early stages.
5 citations
,
July 2010 in “Archives of Internal Medicine” This study observed that topical prostaglandin treatments may protect against hair follicle injury during chemotherapy, as indicated by preserved eyelashes in patients using these treatments.
October 2023 in “Recent Trends in Pharmaceutical Sciences and Research” This review examines the anatomy and physiology of hair, focusing on the hair growth cycle and various types of alopecia, using animal models such as mice and rats to study the condition's pathophysiology and aid in developing new treatments.
5 citations
,
January 2007 in “Immunopharmacology and Immunotoxicology” This study found that 17beta-estradiol enhanced allergy responses in certain age groups of female mice and inhibited thymus involution and regeneration after contact hypersensitivity.
January 2013 in “Revista brasileira de medicina” This article discusses the clinical characteristics and treatment considerations for different types of alopecia, reporting no new research findings.
6 citations
,
January 1994 in “PubMed” This review explores the complexity of the hair cycle and discusses the roles of various growth factors, androgens, and cytokines in regulating hair growth, yet reports no new results.
August 2021 in “EMC - AKOS - Trattato di Medicina” This paper reviews the classification and diagnostic approaches for different types of alopecia, emphasizing the importance of early etiological diagnosis to prevent irreversible hair follicle damage in scarring forms.
3 citations
,
April 2014 in “Journal of Dietary Supplements” This study found that CARI ONE, a herbal mixture, promotes hair growth in mice by inducing the transition from telogen to anagen phase and enhancing hair follicle development, compared to control and minoxidil treatments.
January 2025 in “MEDS Public Health and Preventive Medicine” In this study, oral spermidine supplementation was found to significantly prolong the hair follicle anagen phase and reduce hair loss, with effects persisting three months after treatment in healthy participants, suggesting potential therapeutic benefits for hair loss conditions.
21 citations
,
November 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that telogen, a resting phase of the hair follicle cycle, is characterized by dynamic gene expression, including enhanced cholesterol metabolism and immune signaling, suggesting it is an active regulatory phase despite its quiescent appearance.
February 2010 in “Journal of The American Academy of Dermatology” Mimicking growth factors in a topical solution can prolong hair growth phase and reduce hair loss without side effects.
2 citations
,
January 2020 in “BioMed Research International” This study found that Phaeodactylum tricornutum extract enhanced hair follicle cell proliferation, indicated by increased keratin and ERK1/2 signaling, suggesting its potential for hair care applications.
370 citations
,
September 1999 in “The New England Journal of Medicine” This article discusses the treatment of androgenetic alopecia and alopecia areata with finasteride and minoxidil but reports no new clinical results.
277 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
124 citations
,
August 1994 in “Journal of Investigative Dermatology” This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.
96 citations
,
October 2000 in “The FASEB Journal” In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.
January 2012 in “Journal of the Dermatology Nurses’ Association” The document explains hair growth, hair loss types, and other hair-related terms.
2 citations
,
June 2001 in “American Journal of Pathology” This article explores the complexity and significance of the hair follicle, emphasizing new insights into its biological roles and the involvement of p53 in follicular regression.