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Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Telogen effluvium is a reversible hair loss condition that requires a detailed diagnosis and often resolves on its own.

Androgens can both increase and decrease hair growth in different parts of the body.

PGD2 stops hair growth and is higher in bald men with AGA.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

New effective scar treatments are urgently needed due to the current options' limited success.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Different types of stem cells and their environments are key to skin repair and maintenance.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.