94 citations
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April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study describes the first case of female pseudohermaphroditism due to a novel homozygous glucocorticoid receptor gene mutation, indicating possible pre- and postnatal virilization in affected females.
April 2019 in “Journal of the Endocrine Society” This case report highlighted rapid virilization in a woman with adrenocortical carcinoma, stressing the importance of androgen evaluation to suspect underlying ovarian or adrenal tumors.
June 2003 in “Obstetrical & Gynecological Survey” This study observed that the size of vaginal prolapse in patients was significantly related to both the preoperative vaginal length and the length of vaginal excision during the Michigan four-wall sacrospinous suspension procedure.
March 2026 in “JCEM Case Reports” In this case report, a 71-year-old woman with severe hyperandrogenism and virilization revealed a bilateral ovarian steroid cell tumor, confirmed after adnexectomy, resulting in normalized testosterone levels and improved hirsutism post-surgery.
6 citations
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April 2009 in “Fertility and Sterility” Finasteride helps induce ovulation in nonresponder PCOS women.
November 2014 in “Elsevier eBooks” This article reviews the clinical and biochemical features of genetic mutations affecting dihydrotestosterone production and their potential role in male pseudo-hermaphroditism, but presents no new clinical results.
26 citations
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September 2005 in “Pharmacology Biochemistry and Behavior” This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.
38 citations
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May 1971 in “Clinical genetics” This study suggests 5α‐androstan‐3α‐17β‐diol may be the true inducer of kidney enzymes in certain mice, while its induction mechanism likely involves pinocytosis rather than a receptor protein.
January 2011 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” This case study reported hyperandrogenism in non-obese triplet sisters with one sister's hyperthyroidism masking its clinical and biochemical signs until treatment increased her androgen levels and hirsutism.
July 2001 in “Pediatrics in review” This case describes a 14-year-old girl whose symptoms of hirsutism and virilization were attributed to an ovarian Sertoli-Leydig tumor, with improvement following surgical removal.
September 2018 in “Translational andrology and urology” This study explored the effects of MOTILIPERM on infertility in a rat model with varicocele and oxidative stress, reporting its potential therapeutic efficacy.
118 citations
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May 2003 in “Toxicological Sciences” This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.
1 citations
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January 2016 in “Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma” This article discusses congenital adrenal hyperplasia due to 21 hydroxylase deficiency as a cause of ambiguous genitals in 46XX individuals and reports no new research findings.
32 citations
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January 2010 in “Journal of Korean Medical Science” This case report describes a rare instance of functioning adrenocortical oncocytoma in a 14-year-old girl with virilization and reviews related literature.
4 citations
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June 2002 in “Veterinary Dermatology” In this study, prenatal exposure to all-trans-retinoic acid in pregnant mice resulted in increased BrdU-positive nuclei in hair bulbs without altering hair follicle morphogenesis, suggesting potential for non-teratogenic studies on skin diseases.
April 2023 in “Research Square (Research Square)” This case study of a young Palestinian woman illustrates the diagnostic and treatment challenges of ovarian steroid cell tumors, highlighting the importance of detailed examination when hormonal therapy fails.
9 citations
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August 1952 in “The Journal of Clinical Endocrinology & Metabolism” This study describes a method to estimate endogenous hormone production by neutralizing an endogenous hormone with an oppositely acting hormone.
9 citations
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January 1997 in “Endocrine Journal” This study found a significant association between patients' sex of rearing and external genitalia in those with gonadal dysgenesis, while noting lower testosterone levels compared to controls.
November 2012 in “Experimental and Clinical Endocrinology & Diabetes” This case report describes a 46,XY female patient with a novel homozygous nonsense mutation in the LHCGR gene, highlighting the need for molecular analysis in disorders of sexual development.
4 citations
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September 2010 in “Medical Hypotheses” October 2019 in “Bioscientifica Proceedings” This review discusses the roles of androgens in female mammals, focusing on how androgen receptor activity in pig reproductive organs may influence ovulation rate and litter size, but reports no new experimental results.
2 citations
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September 1971 in “Metabolism, clinical and experimental” In this study, patients with testicular feminization syndrome showed limited anabolic responsiveness to dihydrotestosterone, potentially due to reduced affinity of nuclear receptor sites for androgenic steroids rather than defective testosterone conversion.
October 2024 in “Journal of the Endocrine Society” In this case report, a 62-year-old woman with hyperandrogenism and polycythemia was diagnosed with a rare ovarian steroid cell tumor, highlighting the importance of considering such tumors in similar presentations; surgical removal led to symptom and lab normalization.
6 citations
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October 2018 in “Endocrinology” This study indicates that sheep prenatally androgenized with testosterone show wool fiber diameter changes that parallel the increased hair diameter in women with polycystic ovary syndrome.
August 2013 in “Fertility and Sterility” This in vitro study suggests that factors in the serum of PCOS patients may contribute to ovarian dysfunction, evidenced by higher hormone production and primordial follicle survival compared to control sera.
June 2025 in “General medicine and Clinical Practice” This study found that a lifestyle modification program significantly improved androgenic alopecia, acne vulgaris, and hirsutism levels in infertile overweight and obese women, with 36.2% achieving pregnancy post-intervention compared to none before, suggesting enhanced fertility and reduced hyperandrogenism.
September 2018 in “Fertility and Sterility” This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.
January 2026 in “Brazilian Journal of Development” This case study reported on a 62-year-old woman with ovarian hyperthecosis, which caused symptoms like hirsutism and elevated testosterone; after bilateral oophorectomy, her symptoms improved, suggesting the importance of considering this rare condition in hyperandrogenism diagnosis for postmenopausal women.
17 citations
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January 2013 in “Case Reports in Medicine” This review discusses steroid cell tumors of the ovary, their hormone production, symptoms, and evaluation, emphasizing surgery as the key treatment approach; it reports no new clinical results.
2 citations
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July 2012 in “Journal of Pediatric and Adolescent Gynecology” This case report describes an obese young adolescent girl with PCOS who presented with high testosterone levels and severe hyperinsulinemia, successfully treated with continuous combined oral contraceptives.