Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that mercury chloride administration in rats led to decreased intraepidermal nerve fibers and increased Langerhans cells, suggesting small nerve fiber damage after mercury poisoning.

In this phase 2a study of adults with alopecia areata, researchers observed that ritlecitinib treatment did not result in significant differences in brainstem auditory evoked potential changes or axonal swelling compared to placebo, suggesting the dog toxicity findings may not be clinically relevant in humans.

This study found that methylene blue staining may reveal anatomical details of intraepidermal nerve fibre endings in the rat mystacial pad with greater clarity than the zinc iodide-osmium tetroxide technique.

This study observed that methylene blue staining and zinc iodide-osmium tetroxide techniques effectively revealed anatomical details of intraepidermal nerve fibre endings in the rat's mystacial pad, suggesting their potential role in mechanoreception.

In this study, researchers observed that intractable pruritus in anterior chest keloid lesions is linked to increased intraepidermal nerve fibre density and elevated expression of substance P, without differences in Langerhans cells across different keloid regions.

This study observed that the pig integument is similar to human skin in both light and electron microscopy, with minimal postnatal developmental differences noted.

This study observed an association between intense itching in anterior chest keloids and an increased density of nerve fibers in the epidermis, alongside elevated expression of the pruritus mediator substance P, though no difference was found in Langerhans cells related to pruritus, location, or region.

This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.

In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.

This study found histopathological evidence of hypertrophy in nerve endings that may explain the cutaneous neurosensory symptoms in some long COVID-19 patients.

This study demonstrated that human skin can be efficiently reinnervated using human induced pluripotent stem cell-derived neural stem cells, promoting skin vitality and sensory reinnervation comparable to physiological conditions.

This review discusses neuropathic pruritus, detailing its clinical presentations and management strategies, but reports no new clinical results.

This review discusses the potential of exosome therapy for treating diabetic peripheral neuropathy but highlights the need for more robust preclinical trials before clinical application.

In a study on diabetic mice, researchers developed a protein-based hydrogel that leverages zinc ions and the natural compound phellopterin to promote cutaneous nerve regeneration, angiogenesis, and tissue remodeling in diabetic wounds, highlighting its potential for advanced wound therapy.

This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

In this study, a new formulation of human placental extract showed antioxidant and neurite outgrowth activities, significantly reduced hair graying in mice, and alleviated neuropathy symptoms, suggesting potential therapeutic benefits.

Stress may affect hair growth by influencing hair follicle development and could contribute to hair loss.

In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent.

This review discusses various causes and treatments of scalp pruritus, distinguishing between conditions with primary skin lesions and those without, but provides no new clinical results.

This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.

The document describes various skin conditions, their features, and treatments but lacks detailed study size information.

This article discusses the structure and function of the skin's epidermis, detailing its role as a protective barrier and nutrient exchange system, without presenting new research findings.

This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.

This review discusses the role of Sox2 in skin development, hair follicle regeneration, cancer, and wound healing, and reports no new experimental results.

This article reviews potential causes and treatments for sensitive skin and reports no new clinical results; the authors emphasize neurogenic inflammation and cosmetic choices as key factors in managing the condition.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.