4 citations
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July 2020 in “Journal of Dermatological Treatment” This study found that intralesional minoxidil alone has limited efficacy for non-severe patchy alopecia areata, though it may accelerate hair regrowth compared to spontaneous recovery.
January 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences” In this randomized study, intradermal injections of dutasteride effectively improved androgenetic alopecia in 15 male patients, showing significant clinical improvement within one month and being well-tolerated without notable side effects, though the improvement was negatively correlated with longer disease duration.
June 2024 in “Georgetown Scientific Research Journal” This study found that intradermal bleomycin injections induced dermal fibrosis in C57BL/6 mice, evidenced by hair follicle obliteration and dermal thickening, though no significant trends in gene expression were observed, indicating the need for further research to understand the link between fibrosis and dyschromia.
June 2024 in “Dermatology and therapy” This study reviewed recent advancements in using botulinum toxin for treating androgenetic alopecia and emphasized the need for further research to determine the most effective injection sites and depths, as current strategies show inconsistent results.
March 2024 in “Intisari Sains Medis” This narrative review reported that intradermal injection of autologous platelet-rich plasma showed objective improvement and increased patient satisfaction in treating periorbital wrinkles, though the authors noted the need for further rigorous studies to confirm these findings.
July 2020 in “Journal of The American Academy of Dermatology” This article discusses the authors’ response to comments on their study about intradermal botulinum toxin's effect on androgenetic alopecia, reporting no new findings.
July 2020 in “CRS 2020 Virtual Annual Meeting” This study found that the newly developed microarray patches for intradermal delivery of finasteride showed high drug content and significantly improved skin deposition compared to existing methods.
9 citations
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January 2023 in “Cellular and Molecular Life Sciences” This study found that intrauterine administration of botulinum toxin A improved endometrial environment and receptivity in a murine model of thin endometrium through mechanisms involving IGFBP3 and osteopontin.
60 citations
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January 2023 in “Biomaterials Science” This study reviews recent advancements in microneedles made from PLGA, highlighting their use in delivering vaccines, drugs, and proteins through the skin with minimal invasiveness, and discusses the challenges and future potential of these delivery systems.
11 citations
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November 2023 in “Skin Research and Technology” A 2 mm needle is effective and precise for skin injections.
July 2023 in “Journal of personalized medicine” This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.
55 citations
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May 2017 in “Current stem cell research & therapy” In this study, Japanese patients treated with adipose-derived stem cell-conditioned medium for hair regeneration showed positive outcomes, suggesting it may be an effective new therapy for alopecia.
6 citations
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December 2015 in “Journal of Dermatological Case Reports” This case report highlights that intradermal testing may be more effective than patch testing for diagnosing delayed hypersensitivity reactions to intralesional corticosteroids like triamcinolone acetonide.
45 citations
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April 2016 in “Journal of Dermatological Science” This study found that the Wnt/β-catenin signaling pathway activates melanocyte stem cells, promoting hair follicle regeneration both in vitro and in vivo.
7 citations
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November 2022 in “Communications biology” This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.
6 citations
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September 2019 in “Skin pharmacology and physiology” This study found that RCS-01 cell therapy for aged skin was well tolerated and associated with increased gene expression related to extracellular matrix homeostasis, suggesting potential skin improvement.
June 2026 in “Aesthetic Cosmetology and Medicine” This study reported that patients with mild to detectable androgenetic alopecia showed subjective improvement and a favorable safety profile after receiving a polynucleotide-based intradermal gel, with only one case of mild injection-site erythema noted among 60 participants over three months.
113 citations
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November 2017 in “Scientific Reports” This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
88 citations
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August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
60 citations
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March 2014 in “Veterinary dermatology” This study reported that the prevalence of atopic dermatitis in cats was higher than previously suggested, with severe nonseasonal pruritus most common, and certain breeds were predisposed.
21 citations
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January 2023 in “Biomaterials Science” This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.
19 citations
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January 2017 in “Stem Cells International” This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.
19 citations
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November 1993 in “Mammalian Genome” This study reports that transgene insertion in homozygous transgenic mice causes irreversible hair loss and impaired immune function, linked to interruption of the hairless locus on Chromosome 14.
18 citations
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February 2017 in “Journal of Cosmetic Dermatology” This study reports that mesotherapy for androgenetic alopecia may paradoxically lead to hair loss and scarring, highlighting the need for improved regulation and monitoring of this treatment.
18 citations
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September 2016 in “International Journal of Molecular Sciences” This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.
15 citations
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November 1994 in “International Journal of Dermatology” This study found that while the combination of oral propranolol and intradermal injections in guinea pigs led to psoriasiform changes, it did not fully mimic psoriasis.
15 citations
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September 1984 in “Veterinary Clinics of North America: Small Animal Practice” The document explains various skin conditions in cats and how to diagnose and treat them.
2 citations
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January 2023 in “Dermatologic Therapy” This study found that intradermal injections of autologous cell-free fat extract significantly improved the condition of postinflammatory hyperpigmentation patients, with high patient satisfaction and minimal adverse effects.
2 citations
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July 2019 in “Journal of The American Academy of Dermatology” This letter raises questions for the authors of a recent study on platelet-rich plasma for androgenetic alopecia, without presenting new clinical results.
2 citations
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January 2019 in “Annals of dermatology/Annals of Dermatology” This case report highlights a rare instance of permanent hair loss caused by an allergic reaction to a mesotherapy mixture containing triamcinolone acetonide, suggesting that hypersensitivity reactions to such mixtures are possible.