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Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Topical therapies show promise for hair loss and acne treatment with minimal side effects.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Vitamin D is important for skin health and can help treat psoriasis, atopic dermatitis, and vitiligo.

Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

Lower melatonin levels are linked to more skin aging.

Testosterone in human pancreas cells boosts insulin production.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Coffee bean residue extract helps hair growth by activating cell processes.

Testosterone in our bodies helps increase insulin secretion from the pancreas.

Certain drugs that block specific enzymes can help treat prostate diseases.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Measuring reproductive hormones in brown bear hair could help identify their sex and reproductive state, but better collection methods or lab techniques are needed.

Short-term finasteride treatment may lower some cell death factors in prostate cancer cells.

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Blue light therapy is safe for skin and may protect against UV radiation.

Testosterone therapy can modestly improve sexual function in menopausal women but should be used cautiously and is not recommended for routine measurement in sexual dysfunction or hirsutism.

Hair loss can be caused by stress, aging, and harmful substances that create an imbalance in the body's natural processes.

The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.

Androgenetic alopecia in men is genetic and linked to health issues like obesity and heart disease, with treatments including minoxidil, finasteride, and hair transplants.

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

The skin produces and processes hormones, affecting both local and overall body functions.