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This study found that distinct isoenzymes of 3 beta-hydroxysteroid dehydrogenase are expressed in human adrenals and gonads compared to the placenta and skin.

This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.

This review discusses hormone replacement therapy for menopausal women, emphasizing DHEA's unique ability to convert into sex steroids only in targeted tissues, and reports no new clinical results.

This study found that serum prolactin and dehydroepiandrosterone levels did not determine the onset of mink hair growth cycles, though their metabolites may influence other aspects of hair growth.

This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.

This review discusses the role of DHEA in intracrinology, highlighting its impact on breast and prostate cancer treatment and potential as a menopause therapy, but reports no new research findings.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.

This review discusses how androgens may regulate wound healing and inflammation, noting that testosterone appears to inhibit healing and promote inflammation, but it reports no new clinical results.

This study found that GDNF promotes hair formation and skin wound repair by enhancing the self-renewal and differentiation of bulge stem cells in mice.

This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.

This study found that intracrine androgen signaling via 5α-reductase is essential for optimal endometrial decidualization and vascular development during this process in mice.

This study found that intracrine androgen signaling, mediated by steroid 5α-reductase, is essential for optimal decidualization and vascular development in the endometrium during pregnancy, indicating potential targets for improving age-related fertility issues.

This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.

In this study, higher expression levels of aromatase and steroidogenic acute regulatory protein were correlated with increased estrogen synthesis and fewer hair follicles in human skin, suggesting a link to elastic fiber formation and hair growth.

The article concludes that hormonal therapy is an effective long-term acne treatment, even for those without hormonal imbalances.

In vitro, this study suggests that CRH may act as an autocrine hormone in human sebocytes, influencing lipid synthesis and potentially impacting skin disorders related to alterations in sebaceous lipid formation.

In this study, combining flutamide with finasteride showed additive effects in reducing tumor and prostate growth in a mouse model predictive of androgen-sensitive prostate cancer.

This summary reviews the conflicting reports regarding 17β‐estradiol's effects on hair follicle growth, highlighting potential estrogen receptor-mediated impacts and calling for further research.

In this study of Danioninae species, researchers reported that the presence of breeding tubercles on the pectoral fins is conserved in certain species and linked to local androgen conversion, with steroid 5-α-reductase playing a crucial role in their development.

This review discusses the skin's role in producing hormones and related substances, highlighting their potential in homeostasis and disease management, and reports no new clinical findings.

This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.

This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.

In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.

This study indicates that targeting the PTH/PTHrP receptor may potentially stimulate hair growth, particularly for chemotherapy-induced alopecia, as observed in hairless and cyclophosphamide-treated mice.