research Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients
Higher TGF-β signaling may increase skin cancer risk in organ transplant recipients.
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research Notch Signaling in Hair Follicle Development
The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.
research Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells
Myristoleic acid helps hair growth by boosting cell growth and recycling processes in hair follicle cells.
research XEDAR Activates the Non-Canonical NF-κB Pathway
XEDAR triggers a specific signaling pathway in cells.
research Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle
Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.
research How Does Altered Metabolism Lead to Seizure Control? Partially Filling the Knowledge Gap
Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.
research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds
Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.
research Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats
The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.
research Identification of Key Pathways and Genes That Regulate Cashmere Development in Cashmere Goats Mediated by Exogenous Melatonin
Melatonin affects cashmere growth in goats by influencing stem cell and certain signaling pathways.
research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles
Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.
research The Role of Smads in Skin Development
Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.
research Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology
Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.
research The Negative Regulator CXXC5: Making WNT Look a Little Less Disheveled
CXXC5 is a protein that prevents hair growth and could be a target for hair loss treatment.
research Androgens and Androgen Receptor Action in Skin and Hair Follicles
Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.
research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss
Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.
research The Role of P-Cadherin in Skin Biology and Pathology: Lessons from the Hair Follicle
P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.
research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation
Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
research The Hair Follicle as an Estrogen Target and Source
Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
research Molecular Biology of Hair Morphogenesis: Development and Cycling
Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.
research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla
Male pattern baldness involves hormones and cell signals affecting hair growth.
research Targeting the Wnt Pathways for Therapies
Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
research Hardwiring Stem Cell Communication Through Tissue Structure
The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells
Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.
research Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin
Olive leaf compound oleuropein helps grow hair in mice.
research Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes
Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.
research The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells
Activated platelet-rich plasma helps hair growth by boosting growth factors and cell growth pathways in hair cells.
research Heterogeneity of Neural Crest-Derived Melanocytes
Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.
research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways
Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
research Sphingolipid Metabolism Orchestrates the Establishment of the Adult Hair Follicle Stem Cell Niche to Control Skin Homeostasis
A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.
research Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome
Skin lesions in Carney complex are likely caused by a specific group of skin cells that promote pigment production due to a genetic mutation.