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The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

Surgery is the main treatment for liver hydatidosis, but has risks; albendazole is the most effective drug but can have side effects.

More men are getting benign prostatic hyperplasia, and there are many treatments, from medication to surgery, with new methods being developed.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

The document says to treat cat fungal infections with medicine and clean the environment, noting that cats without symptoms can still spread it to humans.

New genes and pathways are important for testosterone production and male sexual development.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Patients with Bohring-Opitz syndrome and ASXL1 mutations need regular kidney ultrasounds to check for tumors.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

Microsurgical reconstruction effectively covers complex scalp defects but doesn't improve survival for cancer-related cases.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

Microencapsulation helps protect and track therapeutic cells, showing promise for treating various diseases, but more work is needed to improve the technology.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.