July 2017 in “Cancer Research” This study identified a radio-resistant population of Krt15+ stem cells in the mouse small intestine that can initiate tumors, suggesting potential targets for colon cancer therapy.
27 citations
,
February 2020 in “EMBO Reports” This study concluded that MEX3A is critical for maintaining Lgr5+ intestinal stem cells by regulating the PPARγ pathway, impacting intestinal homeostasis during postnatal development in mice.
181 citations
,
December 2017 in “Trends in immunology” This review discusses the roles and interactions of intestinal intraepithelial lymphocytes in maintaining mucosal barrier integrity and highlights how their dysregulated responses may contribute to intestinal pathologies.
9 citations
,
August 2024 in “Pharmacological Reviews” This review summarized advancements in intestinal lymphatic drug delivery, emphasizing the evolving understanding of lymphatics as active players in health and disease, which has led to innovative therapeutic strategies and enhanced pharmacokinetic outcomes via this delivery route.
December 2023 in “Journal of nutritional science and vitaminology” This study in mice found that a zinc-deficient diet suppressed body weight gain and increased kidney and cecum tissue weight without decreasing serum alkaline phosphatase activity. Additionally, zinc deficiency caused alopecia and intestinal changes in C57BL/6J mice, potentially affecting nutritional status.
29 citations
,
March 2012 in “Stem Cell Research & Therapy” This article explores questions about dormant hematopoietic stem cells and suggests avenues for future research, but does not present new experimental results.
28 citations
,
February 2019 in “Genes” This review discusses the regulation and dynamics of the Wnt/β-catenin signaling pathway in development, pluripotency, and cancer, highlighting potential mechanisms and future research directions, but reports no new results.
24 citations
,
May 2016 in “Stem Cell Reviews and Reports” This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.
1 citations
,
June 2022 in “Pharmaceutics” This study found that paracellular transport significantly contributes to the intestinal permeability of minoxidil, suggesting its limited suitability as a Biopharmaceutics Classification System reference drug due to potential variability.
December 2023 in “Frontiers in microbiology” This study reported that mannan oligosaccharides improved the fur quality, immune response, antioxidant status, and gut microbiota of fur-growing raccoon dogs, suggesting they could potentially replace antibiotics in their diet.
82 citations
,
April 1981 in “Clinical endocrinology” This study describes a case of vitamin D resistant rickets in a young girl due to end organ unresponsiveness, highlighting a possible new subtype of the disorder with distinct clinical features.
27 citations
,
July 1946 in “The journal of nutrition/The Journal of nutrition” This study found that adding inositol or biotin to a pig's diet without sulfathalidine had no effect on growth or feed efficiency, but both helped alleviate deficiency symptoms caused by sulfathalidine.
14 citations
,
August 2016 in “Journal of nanomedicine research” This animal study found that biscuits fortified with zinc oxide nanoparticles improved growth, appetite, and hair growth in zinc-deficient rats more effectively than traditional zinc forms, without apparent toxicity.
1 citations
,
October 2023 in “Animals” This study found that supplementing raccoon dogs' diets with 0.25 g/kg Platycladus orientalis leaf extract improved growth performance and altered intestinal microbiota, but higher doses may have adverse effects.
75 citations
,
September 2016 in “EMBO journal” This study found that PRC2 plays a crucial role in maintaining intestinal homeostasis by supporting progenitor cell proliferation and limiting secretory lineage differentiation.
54 citations
,
June 2018 in “Nutrients” This review discusses the diverse extra-intestinal manifestations of celiac disease in children and reports no new clinical results; the authors note differences in symptom prevalence and resolution compared to adults.
November 2013 in “John Wiley & Sons, Ltd eBooks” The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.
65 citations
,
November 2016 in “Journal of The American Academy of Dermatology” This article reviews various types of primary cicatricial alopecias and emphasizes the importance of accurate diagnosis to improve management strategies, particularly detailing remaining lymphocytic forms and expanding on neutrophilic and mixed types.
34 citations
,
August 2002 in “British Journal of Dermatology” This study observed that two patients treated with interferon α-2b and ribavirin for chronic hepatitis C experienced complete and reversible straightening of their natural curly hair, which recurred with treatment resumption.
This chapter classifies various benign skin tumors and discusses their characteristics, treatment indications, and potential for recurrence, but reports no new clinical findings.
14 citations
,
December 2010 in “Journal of human genetics” This study identified a severe MBTPS2 gene mutation in a Japanese patient with IFAP syndrome, suggesting other factors may influence the varied clinical severity of the condition.
11 citations
,
January 2013 in “Postępy Dermatologii i Alergologii” This review discusses various theories of skin aging and the importance of using professional and at-home skincare solutions, but offers no new empirical findings.
7 citations
,
November 2023 in “Microorganisms” This study suggests that the intestinal microbiota may have protective effects against celiac disease by degrading gluten and maintaining intestinal barrier integrity, but disruptions in the microbiota can exacerbate the disease.
6 citations
,
October 2022 in “Frontiers in Cell and Developmental Biology” This study suggests that hair follicle mesenchymal stem cells may alleviate small intestinal ischemia-reperfusion injury in rats by promoting angiogenesis, reducing apoptosis, and enhancing intestinal stem cell expression.
17 citations
,
June 2022 in “Frontiers in Nutrition” This study found that fermented Flammulina velutipes polysaccharides showed higher antioxidant and anti-inflammatory capacities than non-fermented ones, suggesting potential use in functional foods and health products.
14 citations
,
June 2009 in “Journal of veterinary internal medicine” This study describes presumed albendazole toxicosis in alpacas, suggesting that repeated doses as low as 19 mg/kg can lead to severe neutropenia, enteropathy, and potentially death in this species.
16 citations
,
April 2024 in “Proceedings of the National Academy of Sciences” This study found that selectively targeting HDAC4 and HDAC7 in mice can reduce Th17 cell-mediated intestinal inflammation, suggesting a potential treatment approach for Th17-related inflammatory diseases like ulcerative colitis.
3 citations
,
January 2021 in “Oxidative Medicine and Cellular Longevity” In this study, Nrf-2-expressing hair follicle mesenchymal stem cells showed the most significant therapeutic effect in a rat model of ulcerative colitis, suggesting a new potential treatment for the disease.
63 citations
,
November 2012 in “Journal of Cellular Biochemistry” This paper discusses the role of Runx1 in epithelial biology and pathology, highlighting its dual function as a tumor promoter and suppressor in different contexts, and reports no new experimental findings.
June 2023 in “Journal of Biological Chemistry” In this study, the authors identified and characterized the Get3d protein, conserved across plants and photosynthetic bacteria, which localizes to the chloroplast in Arabidopsis thaliana and potentially plays a role in tail-anchored protein targeting, linked to photosynthesis homeostasis.