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Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Interferon and ribavirin can cause serious skin reactions and other health issues.

Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Human skin cells have a high-affinity system for biotin transport, crucial for skin health.

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

Understanding hair follicles through various models can help develop new treatments for hair disorders.

Anticancer drugs like methotrexate and trimetrexate could be effective and safe for treating malaria at low doses.

Vitamin D might help regulate insulin in the body, but taking Vitamin D supplements doesn't clearly prevent or improve type 2 diabetes. More research is needed.

Photobiomodulation therapy helps manage cancer treatment side effects but needs more research for optimization.

The document says that hirsutism in women usually needs hair removal and hormone treatment to manage symptoms and improve well-being.

Tailored treatments for alopecia areata are recommended based on severity and patient needs.

The document suggests a possible link between FAM111B gene mutations and increased cancer risk, particularly pancreatic cancer.

The conclusion is that certain dog and cat breeds are prone to Malassezia dermatitis, which can be diagnosed with skin tests and treated with antifungal shampoos or medications, and preventing relapses involves managing underlying issues and maintaining good hygiene.

Polycystic ovary syndrome (PCOS) was first described in 1721, officially diagnosed in the 1990s, and is now known to be partly genetic and linked to insulin resistance, with increased risk of cardiovascular disease and carbohydrate metabolism issues.

The drug combination was safe and showed promise in treating advanced tumors.

Ovarian drilling surgery is not clearly better than medical treatments for PCOS symptoms.

T-cells in alopecia areata scalp show abnormal regulation, leading to less inflammation.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

KCNQ potassium channels help control the sensitivity of touch receptors in the skin.

A woman with lupus and severe nerve damage improved with specific treatments.

Anti-TNF therapy can cause weight gain and hair loss, leading some patients to stop treatment.

Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.

Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.

Skin stem cells are promising for healing wounds and skin regeneration due to their accessibility and regenerative abilities.

Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.

Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.

Higher lead and cadmium, and lower zinc and iron levels in the blood might be linked to chronic hair loss in women.

The cat's hypothyroidism was successfully managed with levothyroxine, leading to a stable condition.