research Topical Application of the Wnt/β-Catenin Activator Methyl Vanillate Increases Hair Count and Hair Mass Index in Women with Androgenetic Alopecia
Methyl vanillate spray increases hair count and hair mass in women with hair loss.
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research An Incompletely Penetrant Novel MAFB (p.Ser56Phe) Variant in Autosomal Dominant Multicentric Carpotarsal Osteolysis Syndrome
Researchers found a new gene variant linked to a rare bone disease, which doesn't always cause symptoms in carriers.
research Inhibition of 3-Methylcrotonyl-CoA Carboxylase Explains the Increased Excretion of 3-Hydroxyisovaleric Acid in Valproate-Treated Patients
Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.
research Rapid Determination of Minoxidil in Human Plasma Using Ion-Pair HPLC
Quick method to measure minoxidil in blood, accurate and useful for labs.
research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation
Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.
research Multiple Readout Assay for Hormonal (Androgenic and Antiandrogenic) and Cytotoxic Activity of Plant and Fungal Extracts Based on Differential Prostate Cancer Cell Line Behavior
The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.
research Androgenic and Anti-Androgenic Effects of Progesterone Derivatives with Different Halogens as Substituents at the C-6 Position
Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.
research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration
Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.
research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation
Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.
research Geranylated Coumarins From Thai Medicinal Plant Mammea Siamensis With Testosterone 5α-Reductase Inhibitory Activity
Compounds from the plant Mammea siamensis may help treat hair loss.
research AKR1D1 Regulates Glucocorticoid Availability and Glucocorticoid Receptor Activation in Human Hepatoma Cells
AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
research Fluridil, A Rationally Designed Topical Agent For Androgenetic Alopecia: First Clinical Experience
Fluridil safely promotes hair growth in men with androgenetic alopecia.
research TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model
Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.
research Oxidative Modification in Human Hair: The Effect of the Levels of Cu (II) Ions, UV Exposure and Hair Pigmentation
Reducing copper (II) ion levels in hair can decrease hair damage.
research Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles
Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.
research Factors Influencing Hydrocortisone Permeation Into Human Hair Follicles: Use of the Skin Sandwich System
Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.
research Stereocontrolled Synthesis of All Eight Stereoisomers of the Putative Anti-Androgen Cyoctol
Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.
research Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite
Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
research Investigation of Transfollicular Caffeine Penetration Using Microdialysis on Ex Vivo Porcine Ear Skin
Caffeine penetrates skin quickly through open hair follicles, but less through closed ones, with levels becoming equal after 22 hours.
research Palladium Nanoparticles on a Pyridinium Supported Ionic Liquid Phase: A Recyclable and Low-Leaching Palladium Catalyst for Aminocarbonylation Reactions
The new palladium catalyst is effective and reusable for making pharmaceutical ingredients.
research Development of Optimized Self-Nanoemulsifying Lyophilized Tablets to Improve Finasteride Clinical Pharmacokinetic Behavior
Improved tablets lead to faster, better drug absorption for hair loss treatment.
research Lanostane-Type Triterpenes from the Sclerotium of Inonotus Obliquus (Chaga Mushrooms) as Proproliferative Agents on Human Follicle Dermal Papilla Cells
Chaga mushrooms contain compounds that may promote hair growth better than common treatments.
research Bioactive Compounds from the Roots of Asiasarum Heterotropoides
Two compounds from Asiasarum heterotropoides roots show potential as lung cancer treatments without harming normal cells.
research In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
Ketoconazole increases finasteride's effectiveness and lifespan in the body.
research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors
Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.
research In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions
Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.
research Modulation of the 6-Position of Benzopyran Derivatives and Inhibitory Effects on the Insulin Releasing Process
Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.
research Urinary Steroids in Men with Male-Pattern Alopecia
Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.
research Plasma Androsterone/Epiandrosterone Sulfates as Markers of 5α-Reductase Activity: Effect of Finasteride in Normal Men
Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.
research Nutraceutical and Functional Scenario of Wheat Straw
Wheat straw is valuable for its health benefits and various industrial uses.