research Skin, Genetic Defects, and Aging
Genetic defects and UV radiation cause skin damage and aging.
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research Morphological Characteristics and Notes of the Skin in Preclinical Toxicity Assessment
Skin structure complexity and variability are crucial for assessing skin toxicity in safety tests.
research Scratching the Surface of Skin Development
The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
research Perspectives on Hair Evolution Based on Comparative Studies on Vertebrate Cornification
Hair in mammals likely evolved from glandular structures, not scales.
research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle
Trichohyalin is a protein in hair follicles that helps form hair filaments.
research Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target
CD2 might be a new treatment target for patchy alopecia areata.
research Homo- and Heteropolymer Self-Assembly of Recombinant Trichocytic Keratins
Recombinant keratins can form useful structures for medical applications, overcoming natural keratin limitations.
research Action of Thioglycolic Acid and L-Cysteine on Disulfide Cross-Links in Hair Fibers During Permanent Waving Treatment
Thioglycolic acid and L-cysteine change hair structure differently during perms, affecting hair strength and curling efficiency.
research From Structural Resilience to Cell Specification: Intermediate Filaments as Regulators of Cell Fate
Intermediate filaments are crucial for cell differentiation and stem cell function.
research Structural Analysis of Curly and Straight Human Hair Fibers by Scanning Microbeam SAXS
Curly and straight hair differ in how their internal fibers are arranged.
research A Comparative Study of Materials Assembled from Recombinant K31 and K81 and Extracted Human Hair Keratins
Recombinant keratin materials may better promote skin cell differentiation than natural keratin.
research The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17
AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.
research Review: Evolution And Diversification Of Corneous Beta-Proteins, The Characteristic Epidermal Proteins Of Reptiles And Birds
Corneous beta-proteins evolved uniquely in reptiles and birds, forming scales, claws, beaks, and feathers.
research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes
A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.
research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules
PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.
research Nestin as a Marker of Unipotent Embryonic and Adult Progenitors Differentiating into an Epithelial Cell Lineage of the Hair Follicles
Nestin identifies specific progenitor cells in hair follicles that can become outer root sheath cells.
research Evolution of Trichocyte Keratins
Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.
research Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility
Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.
research Effect of Shampoo, Conditioner, and Permanent Waving on the Molecular Structure of Human Hair
Perming significantly changes hair's molecular structure, while shampoo and conditioner do not.
research The Epidermis: Rising to the Surface
The document concludes that recent research has improved understanding of skin diseases and the balance between cell growth and differentiation in the epidermis.
research Keratin Expression by Corneal and Limbal Stem Cells During Development
Different types of cells in the eye express specific keratins at various stages of development.
research A Splice Variant in KRT71 Is Associated with Curly Coat Phenotype of Selkirk Rex Cats
A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.
research Discussion: Themes in the Molecular Structure of Hair
Keratin proteins are crucial for hair structure and strength.
research Formation of the Cornified Envelope
The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.
research George Ernest Rogers 1927–2021
George Ernest Rogers was a notable scientist who made important discoveries about hair and wool proteins.
research Keratin and Skin Disorders
Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.
research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome
The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.
research Keratin 71 Mutations: From Water Dogs to Woolly Hair
A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.
research Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation
Calcium reduces involucrin in rat hair bulbs but doesn't affect filaggrin and Kdap.
research Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles
Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.