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This study found that fibronectin supports hair follicle regeneration by influencing stem cell behavior through integrin-dependent mechanotransduction, highlighting its potential role in epidermal renewal.

This study summarizes the signaling molecules and extracellular components involved in epithelial–mesenchymal interactions, enhancing our understanding of hair follicle regeneration and skin wound healing, but reports no new experimental results.

This paper discusses the multipotency of cyst cells and proposes that understanding molecular circuits in cyst formation could enable engineering of desired stem cell culture phenotypes, but reports no new experimental outcomes.

Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.

This review highlights the multifaceted roles of hair follicles in skin health, emphasizing their contribution to skin tumorigenesis, homeostasis, and wound healing, and how dysregulation in associated pathways like Wnt, Hedgehog, and Notch may contribute to skin cancer development.

This review discusses cutaneous extramedullary haematopoiesis and its potential mechanisms but reports no new clinical findings.

This study proposes a two-step method that may enhance the generation of stem-like epidermal cells with superior proliferation and differentiation potential for skin regeneration.

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

This study found that KY19382, a small molecule activating the Wnt/β-catenin pathway, significantly improved wound healing by enhancing cell migration, increasing collagen and stem cell markers, and accelerating re-epithelialization and neo-epidermis formation in a murine model without causing significant cytotoxicity.

This review analyzed 17 recent clinical trials on platelet-rich plasma for androgenetic alopecia but reports no new clinical results; the authors seek a consensus on optimal PRP use.

This study used an ex vivo human skin model to show that tropical conditions disrupt skin homeostasis, resulting in epidermal thickening and junctional flattening, and found that Kombucha tea extract may help preserve skin structure under such stress.

This study by Flores and colleagues found that the type of tumor that develops in a specific subset of epidermal stem cells is influenced by which tumor suppressor gene is deleted.

This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This study revealed that during fetal development, MITF and Mart-1 expressing melanocytes progress from the dermis to the epidermis and hair follicles, with MITF possibly marking follicular stem cells.

This study indicates that transient Msx2 expression is critical for wound-induced hair follicle neogenesis, with distinct phases in the healing process essential for epidermal competence and hair regeneration.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

This study found that human hair follicles serve as a crucial reservoir for Langerhans cells, which repopulate the epidermis depleted by ultraviolet B exposure.

This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.

This study suggests that IGFBP-2 may play a role in basal cell carcinoma development by mediating epidermal progenitor cell expansion in hair follicles with activated Shh signaling.

This study found that bulge-derived keratinocytes from human follicles were more resistant to differentiation compared to epidermal keratinocytes, possibly due to WIF-1 involvement.

This study found that αvβ6 integrin inhibits keratinocyte proliferation during wound healing and hair regeneration, suggesting its downregulation may enhance recovery and influence epidermal stem cell behavior.

In this study, CTCF was found to play essential roles in epidermal differentiation and skin barrier formation, simultaneously acting as a suppressor of epithelial inflammatory responses in mouse skin.

This study found that Schistosoma mansoni cercariae stimulate epidermal keratinocytes in mice, initiating pro-inflammatory responses and barrier repair mechanisms akin to those in wound healing.

This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.

In this study, the authors identified a role for hair follicles in regulating the formation and sympathetic innervation of arrector pili muscles, influencing hair follicle stem cell activity and potentially explaining hair loss associated with beta-blockers and androgenic alopecia.

This study found that in neonatal mice, the absence of the NG2 proteoglycan leads to reduced epidermal thickness and delayed subcutis thickening due to impaired proliferation and adipocyte deficiencies.

In a keratinocyte-specific knockout mouse model, this study found that deleting GRK2 disrupted hair follicle homeostasis, causing cyst-like structures, abnormal growth patterns, and eventual hair loss, suggesting potential links to immune-mediated alopecias.

In this study, researchers developed a new murine model for transplanting vibrissae that mimics human hair transplantation, achieving successful hair growth in immune-deficient nude mice.