23 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses the role of defensin peptides in stem cell activation for potential skin rejuvenation therapies and reports no new clinical findings, emphasizing the need for further studies.
16 citations
,
October 2013 in “Irish Veterinary Journal” This case study describes the successful use of recombinant feline interferon-omega in managing feline chronic gingivostomatitis syndrome in cats with type II diabetes, where long-acting corticosteroids are contraindicated.
16 citations
,
December 2011 in “Actas Dermo-Sifiliográficas” This review discusses the current understanding of propranolol's use in treating infantile hemangiomas, covering its indications, effectiveness, side effects, and ongoing clinical trials, without presenting new clinical results.
14 citations
,
January 2016 in “Annals of dermatology/Annals of Dermatology” This study found that oral cyclosporine was more effective and had fewer side effects than betamethasone minipulse therapy for treating alopecia areata.
11 citations
,
November 2019 in “Clinical Case Reports” This study highlights that while there are no FDA- or ANVISA-approved treatments for children with alopecia areata, JAK inhibitors are emerging as a promising therapeutic option for this population.
10 citations
,
January 2016 in “Global Dermatology” This study observed that zinc deficiency in humans and mice was associated with diminished allergic contact dermatitis but increased severity and duration of irritant contact dermatitis.
4 citations
,
January 2011 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study demonstrated that vitamin B12 may promote hair growth in vitro by modulating intracellular signaling in the wnt-pathway, suggesting potential benefits for micrograft transplantation.
March 2017 in “Trichology and cosmetology:” Psoriasis treatment may affect body hair growth, with a complex relationship between skin and hair growth mechanisms.
December 2025 in “Cosmoderma” This study reviewed evidence suggesting that systemic corticosteroids, particularly in pulse regimens like dexamethasone and betamethasone oral mini-pulse, effectively slow vitiligo progression and support repigmentation, while offering a favorable safety profile compared to continuous therapy.
8 citations
,
January 2017 in “Elsevier eBooks” This review discusses the use of nutraceuticals in dermatology for preventing and reversing signs of skin aging, but it reports no new clinical results.
384 citations
,
June 2005 in “Genes & development” This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.
260 citations
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June 2011 in “Cell” This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.
68 citations
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April 2002 in “Journal of Alternative and Complementary Medicine” This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.
54 citations
,
September 2012 in “Dermatologic Clinics” This review discusses possible medication-induced hair loss and the need to exclude other confounding factors like stress and illness; it reports no new clinical findings and emphasizes careful assessment before attributing hair loss to medications.
28 citations
,
March 2017 in “Endocrinology” In this study, the researchers found that vitamin D and calcium signaling in keratinocytes are essential for normal skin regeneration after wounding, with deficiencies significantly delaying wound closure and re-epithelialization in mice.
19 citations
,
January 2018 in “BioMed Research International” This study suggests that miRNAs, particularly miR-195-5p, may regulate the loss of hair follicle inductivity in cultured dermal papilla cells by suppressing the Wnt/β-catenin pathway.
17 citations
,
June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This review explores theories on the evolution of hair from synapsid scales and glands, proposing mechanisms supported by comparative studies, but reports no new experimental findings.
15 citations
,
August 2022 in “Journal of endocrinological investigation” This review discusses how vitamin D and calcium signaling are essential for wound healing by activating epidermal and hair follicle stem cells, noting that deficiencies may lead to delayed or chronic wounds.
9 citations
,
April 2006 in “American Journal of Pathology” This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.
7 citations
,
December 2015 in “Experimental Dermatology” The study found that Sh-Polypeptide 9, a biomimetic peptide, enhances endothelial tubulogenesis and VEGF production more effectively than minoxidil, particularly at low concentrations, suggesting potential for hair follicle vascularization.
6 citations
,
November 2018 in “Histochemistry and Cell Biology” This study observed that gerbils exhibit a different wound healing mechanism compared to mice, with lower TGF-B1 expression and distinct tissue responses, yet achieve similar healing outcomes.
6 citations
,
September 2015 in “Journal of Investigative Dermatology” This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.
3 citations
,
February 2022 in “Frontiers in cell and developmental biology” This study found that the circular RNA circCOL1A1 influences the formation of superior-quality brush hair in white goats by regulating hair follicle stem cell behavior and interacting with the miR-149-5p/CMTM3/AR axis.
3 citations
,
April 2010 in “Endocrinology” This review discusses the mechanisms of androgenic alopecia and reports no new results; the development of a mouse model for further study is described.
2 citations
,
April 2020 in “International Journal of Dermatology and Venereology” This review summarizes current evidence on how beta-human papillomavirus and Merkel cell polyomavirus may contribute to the development of nonmelanoma and Merkel cell skin carcinomas, respectively, but it reports no new clinical findings.
1 citations
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March 2016 in “Neurotoxicity Research” In this study, finasteride pretreatment led to EEG changes in rats that suggest a mild reduction in thioacetamide-induced hepatic encephalopathy.
1 citations
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July 2012 in “Nasza Dermatologia Online” This study found that patients with alopecia areata had significantly higher serum levels of IL-1α compared to healthy controls, with no significant difference observed in IL-1β levels.
December 2025 in “Frontiers in Immunology” This review highlights that disturbances in neuroimmune communication, particularly between sympathetic nerves and macrophages, may contribute to autoimmune diseases like rheumatoid arthritis and type 1 diabetes, and suggests potential therapeutic avenues by restoring this communication in preclinical and early clinical studies.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.
This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.