This study in female Wistar albino rats found that Pluronic F127-stabilized nanostructured lipid carriers with tea seed or lavender oil significantly increased hair regrowth and follicular density compared to placebo, showing enhanced efficacy over a commercial product in promoting hair growth.
November 2025 in “Journal of Investigative Dermatology” This study identified nine pathogenic variants in the PADI3 gene and variants in the S100A3 and TCHH genes in patients with central centrifugal cicatricial alopecia, suggesting a broader genetic basis for the disease and potential targets for genetic testing and therapies.
November 2025 in “PubMed” This study identified nine pathogenic variants in the PADI3 gene, and variants in the S100A3 and TCHH genes, which may disrupt protein function and contribute to central centrifugal cicatricial alopecia.
October 2025 in “Journal of the Endocrine Society” This research review observed that topical hormone replacement therapy, particularly estradiol and estradiol-testosterone combinations, significantly increased Type I and III collagen synthesis in the skin of postmenopausal women, suggesting benefits against collagen loss-related skin aging effects such as reduced elasticity and increased dryness.
This case report of a four-year-old girl with Nicolaides-Baraitser syndrome highlights severe atopic dermatitis and worsening alopecia, suggesting that SMARCA2 dysfunction may impact skin barrier integrity and hair health, necessitating aggressive dermatologic treatment.
June 2025 in “Cancer Management and Research” This study found that scalp cooling resulted in visible hair retention in 53% of breast cancer patients undergoing Epirubicin/Cyclophosphamide and Paclitaxel treatment, with factors like hair bulb diameter, shaft diameter, and anagen rate significantly predicting outcomes.
April 2025 in “Research Journal of Topical and Cosmetic Sciences” This study found that an anti-dandruff shampoo containing Bromelain effectively preserves hair fiber integrity, enhances uniformity and lustre, and offers therapeutic benefits for scalp infections and inflammation, making it a safer alternative for dandruff treatment.
January 2025 in “International Journal of Molecular Sciences” This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.
July 2024 in “Journal of Investigative Dermatology” The new skin organoid system effectively mimics human skin for studying its functions, injuries, and diseases.
July 2024 in “DOAJ (DOAJ: Directory of Open Access Journals)” This article reviews the effects of vitamins, including A, C, D, E, and B, on animal fur, highlighting their roles in promoting healthy skin and fur condition by regulating cell renewal, metabolism, and collagen synthesis.
November 2023 in “Burns and trauma” This review discusses how the skin microbiome impacts different types of cutaneous wounds, such as acute and chronic, and explores therapeutic strategies targeting the microbiome to enhance healing outcomes.
August 2023 in “Processes” This study found that fermenting Dendrobium officinale with Lactiplantibacillus plantarum CCFM8661 and other strains increased polysaccharide yields and skin care activity, particularly with CCFM8631, which showed significant improvements in skin cell protection and inflammation reduction in both cell cultures and mouse models.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that rare damaging variants in the KRT82 gene, which affect hair shaft integrity, may contribute to the risk of alopecia areata.
August 2019 in “Journal of Investigative Dermatology” This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.
April 2018 in “Journal of Investigative Dermatology” This study found that claudins CLDN1 and CLDN3 are crucial for maintaining proper hair follicle structure in mice, and their dysregulation may lead to telogen hair loss.
January 2014 in “Pathology” Non-scarring hair loss can be diagnosed with two 4mm punch biopsies, one cut vertically and the other transversely.
This study found that chronic administration of finasteride in rats led to significant alterations in the epididymis and compromised sperm quality, effects that persisted even after 30 days of treatment cessation.
75 citations
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April 2000 in “Developmental Dynamics” This study suggests that the structural integrity and physical proximity of Whn's DNA binding and activation domains are crucial for hair keratin gene activation and may explain the nude phenotype.
43 citations
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July 1994 in “Journal of Cell Science” This study found that the extraction-resistant structures in hair, feathers, and hagfish teeth are due to ε-(γ-glutamyl)lysine cross-linked proteins, emphasizing their role in maintaining the integrity of these materials.
17 citations
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June 2019 in “Cellular signalling” Minoxidil treatment in mice preserved the integrity of elastic lamellae and improved arterial biomechanical properties, especially in females, suggesting it could be an anti-arterial aging agent potentially suitable for female-targeted therapies.
6 citations
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May 2009 in “Cell transplantation” This study found that EGCG improved the integrity of skin grafts during cryopreservation, suggesting its potential usefulness for skin preservation, though the exact mechanism remains unclear.
January 2024 in “European journal of endocrinology” The article was retracted due to data integrity issues.
July 2023 in “Hair transplant forum international” This abstract suggests that hair integrity is influenced by both external factors like physical damage and internal factors such as nutrition, and proposes a "hair diet" as a comprehensive approach to address these issues and improve hair health.
September 2007 in “Journal of Investigative Dermatology” ANp63 is crucial for skin integrity, new filaggrin gene mutations link to eczema, hair can regrow from non-stem cells, sunburns are increasing, and glucocorticoids help treat skin allergies by affecting immune cells.
122 citations
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June 2002 in “Genes & Development” This study found that K17 is crucial for the structural integrity and survival of hair-producing cells, with K17 null mice developing alopecia due to hair fragility and follicular alterations.
2 citations
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September 2004 in “Experimental Dermatology” This review discusses how dysfunction in keratinocyte adhesion affects skin integrity and conditions like alopecia and keratoderma, highlighting the roles of intercellular junctions, and reports no new clinical results.
January 2026 in “Brazilian Journal of Pharmaceutical Sciences” This study assessed the effects of chemical treatments on hair fiber integrity and found that conditioners with vegetable oils like jojoba and coconut enhanced hydrophobicity and reduced combing friction except for jojoba, while participants preferred these oil-containing conditioners over the base formulation.
September 2023 in “Journal of Natural Fibers” This study found that using a microfiber towel to dry human hair better preserves hair keratin integrity and wear resistance compared to blow-drying or using a cotton towel, as indicated by stronger alpha-helix structure in FTIR analysis.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study explores how EGFR signaling impacts skin inflammation and follicular integrity during hair eruption, aiming to identify druggable pathways to mitigate skin inflammation in cancer patients receiving EGFR inhibitors.
181 citations
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December 2017 in “Trends in immunology” This review discusses the roles and interactions of intestinal intraepithelial lymphocytes in maintaining mucosal barrier integrity and highlights how their dysregulated responses may contribute to intestinal pathologies.