211 citations
,
May 2018 in “Trends in cell biology” This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.
46 citations
,
June 2015 in “Journal of Investigative Dermatology” This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.
36 citations
,
February 2007 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that vitamin D receptor activation in primary keratinocytes can occur independently of the 1,25-dihydroxyvitamin D3 ligand, likely through interaction with retinoid X receptors.
29 citations
,
January 2021 in “Translational Psychiatry” This study found that certain gene sets, including those involved in ligand-gated ion channel signaling and cell adhesion, are associated with Tourette syndrome, suggesting a potential neurobiological basis for the disorder.
29 citations
,
September 2012 in “Birth Defects Research” This review discusses the developmental regulation of wound healing mechanisms in mammals, focusing on the role of the Wnt and TGF‐β signaling pathways, and reports no new clinical findings.
28 citations
,
March 2016 in “Toxicologic pathology” This review discusses the function and pathology of hair follicles and highlights the potential of using dogs as a model to study human hair and stem cell disorders, but presents no new experimental results.
19 citations
,
September 2019 in “EMBO molecular medicine” This study found that deletion of c-Jun and JunB in mouse bulge hair follicle stem cells was sufficient to trigger psoriasis-like skin disease through thymic stromal lymphopoietin signaling.
16 citations
,
December 2012 in “Bioinformation” This study suggests that natural molecules like curcumin, EGCG, barringtozenol, and finasteride may be effective inhibitors for VEGFR, potentially offering a cancer chemoprevention alternative to pazopanib.
9 citations
,
December 2022 in “Phytomedicine” This review discusses the pharmacology, toxicology, and clinical efficacy of flavonoids and saponins, highlighting the need for more data on their pharmacokinetics, interactions, and toxicities as most research is still in vitro.
6 citations
,
April 2025 in “Communications Biology” In this study, researchers used a murine model of irritant contact dermatitis to reveal that hair follicle regions serve as key sites for neutrophil transepidermal migration, which requires MMP-9 expression stimulated by dermal monocytes.
6 citations
,
October 2016 This article reviews the complex structure and molecular composition of hair keratins, highlighting their self-assembly process and implications for keratin extraction techniques, but reports no new experimental results.
4 citations
,
January 2013 in “Advances in Experimental Medicine and Biology” This article reviews mammalian skin epidermis as a model for studying stem cell regulation, noting the utility of in vitro and ex vivo platforms, but it reports no new empirical findings.
3 citations
,
September 2025 in “ChemMedChem” This review highlights the inadequacy of the "specificity paradigm" in drug design for complex diseases like Alzheimer's and cancer, suggesting a shift toward developing multitarget drugs to improve treatment efficacy by interacting with multiple targets through various mechanisms.
2 citations
,
November 2024 in “Journal of Clinical Medicine” This review suggests that vitamin D3 deficiency and the colonization of oral mucosa by *Candida* fungi may contribute to the pathogenesis of psoriasis, highlighting the potential interaction between vitamin D, microbiome imbalance, and fungal infections in the disease's progression.
1 citations
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March 2014 in “TURKDERM” This review discusses the life cycle and homeostasis of hair follicles, highlighting their development and the complex signaling between dermal and epithelial cells, but it reports no new clinical results.
August 2026 in “Immunity & Inflammation” In this review, the authors discuss how niche-specific immunometabolic regulation influences tissue repair across various organs by highlighting the complex, context-dependent interaction between immune metabolism and tissue-specific regenerative outcomes.
February 2026 in “Advanced Sensor Research” In this review, researchers examined advanced sensing technologies and bioelectronic interfaces that could improve understanding of the skin–brain axis, highlighting challenges and strategies for integrating these platforms into models for studying skin and neural interactions.
May 2023 in “Clinical, Cosmetic and Investigational Dermatology” In this study, human dermal fibroblast-conditioned medium was found to contain numerous proteins involved in wound repair and hair regeneration, with identified proteins forming interaction networks linked to key signaling pathways like epidermal growth factor receptor and transforming growth factor-β.
January 2006 in “Advances in developmental biology” This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.
13 citations
,
November 2023 in “International Journal of Nanomedicine” This review explores the potential of nanofiber scaffolds as an advanced intervention in peripheral nerve regeneration, detailing their fabrication, cellular interactions, controlled bioactive agent release, clinical translation prospects, emerging trends, and biocompatibility considerations for treating peripheral nerve injuries.
1 citations
,
January 2009 in “Trepo - Institutional Repository of Tampere University” This study found that vitamin D regulates cholesterol metabolism and may influence prostate cancer development through mechanisms affecting prostate cell growth and sex hormone metabolism.
November 2023 in “npj regenerative medicine” This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.
163 citations
,
March 2012 in “BMC biology” This forum article in BMC Biology discusses evolving views on the concept of the stem cell niche, highlighting varied mechanisms and the need for better understanding of the niche's roles and functions.
50 citations
,
December 2013 in “Stem Cells” This review discusses the enhanced understanding of how stem cell niches respond adaptively to systemic signals, aging, and local perturbations, but reports no new research findings.
26 citations
,
December 2016 in “Pharmacology & Therapeutics” This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.
6 citations
,
April 2025 in “Plastic and Aesthetic Research” This review highlights that biomaterial properties can be designed to modulate macrophage activity, potentially reducing foreign body responses and enhancing tissue healing in regenerative medicine.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
333 citations
,
February 2010 in “Cell Stem Cell” This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.
228 citations
,
September 2012 in “Trends in Neurosciences” This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.
156 citations
,
December 2012 in “Cell Stem Cell” This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.