November 2004 in “John Wiley & Sons, Ltd eBooks” This chapter reviews polycystic ovary syndrome (PCOS), focusing on its definition, causes, and treatment approaches, but reports no new research findings.
October 2025 in “Indian Journal of Physiology and Pharmacology” This case study suggests a potential connection between insulin resistance-induced diabetes and the development of migraine symptoms in a patient with HAIR-AN syndrome, highlighting the importance of early diagnosis and a multifaceted treatment approach.
February 2025 in “Clinical Cosmetic and Investigational Dermatology” This study used Mendelian randomization analysis to find a significant causal relationship between high fasting insulin levels and androgenetic alopecia, while identifying potential core genes and metabolic pathways that could mediate this link.
This review discusses various syndromes of severe insulin resistance, their biochemical and clinical features, and potential therapeutic options, but it reports no new clinical results.
July 2025 in “Archives of Toxicology” The study introduced an advanced skin model, ImmuSkin-MT, which effectively distinguished between different strengths of skin sensitizers by mimicking the interaction of immune cells in skin tissue.
343 citations
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December 2008 in “Endocrine Reviews” This review discusses the various evidence-based and potential applications of metformin in treating and preventing symptoms and complications associated with polycystic ovary syndrome but reports no new clinical results.
50 citations
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August 2017 in “Diabetologia” This review discusses genetic factors that may influence the effectiveness of metformin in treating polycystic ovary syndrome and emphasizes the need for further research to establish clear benefits.
7 citations
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November 2003 in “Current Opinion in Obstetrics & Gynecology” This review summarizes recent studies on metformin for polycystic ovary syndrome, reporting its beneficial effects on endocrine, metabolic, and reproductive outcomes, but highlights ongoing debate about its mechanisms.
1 citations
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May 2017 in “Maturitas” This review discusses the role of physical activity in healthy aging and reports no clinical results; the authors emphasize the need for integrating exercise into daily life and social settings.
May 2022 in “Maǧallaẗ Buḥūṯ Al-Tarbiyyaẗ Al-Nawʿiyyaẗ (Print)” In this study, a high inositol diet, with or without supplements, significantly improved androgen levels, insulin sensitivity, and certain metabolic indicators in women with PCOS over three months.
February 2020 in “Spiral (Imperial College London)” This study found that duodenal mucosal resurfacing did not significantly improve insulin sensitivity or reproductive function in women with PCOS and insulin resistance compared to a sham procedure.
369 citations
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June 2013 in “Biochimie” This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.
66 citations
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September 2008 in “Dermatologic therapy” This review discusses medical treatments for hirsutism, focusing on oral contraceptives and other therapies, but reports no new results; the authors emphasize the lack of evidence for insulin sensitizers in treating hirsutism alone.
54 citations
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August 2017 in “Gynecological Endocrinology” This review discusses treatments for polycystic ovary syndrome, including lifestyle changes, oral contraceptives, and various medications, and reports no new clinical findings; the authors highlight the potential of statins and inositol for managing symptoms.
40 citations
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April 2008 in “European journal of endocrinology” In this study, treatment with insulin sensitizers significantly increased adipose tissue GLUT4 mRNA expression and improved insulin resistance, menstrual patterns, and androgen profiles in PCOS patients, with rosiglitazone being more effective than metformin.
28 citations
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November 2007 in “Medical Clinics of North America” This review discusses the impact, pathophysiology, and health risks of obesity and the metabolic syndrome in polycystic ovarian syndrome, emphasizing the potential life-saving benefits of recognition and treatment, but it reports no new results.
8 citations
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March 2022 in “International Journal of Endocrinology” This study found that combining low-dose spironolactone with metformin improved insulin resistance in PCOS patients more effectively than using either drug alone.
4 citations
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January 2017 in “Acta Endocrinologica” This study found that both finasteride and metformin effectively reduced androgen levels and insulin resistance parameters in women with PCOS, without clear evidence of one treatment being superior.
1 citations
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December 2015 in “Endocrinology” This study suggests that dietary decanoic acid may manage hyperandrogenism and insulin resistance in PCOS, as observed in animal and cell model experiments.
January 2026 in “International Journal of Unani and Integrative Medicine” This review correlates modern biomedical and Unani medical perspectives on PCOS, suggesting that integrating both approaches might improve symptom management and quality of life for affected women, though it reports no new clinical results.
January 2026 in “Egyptian Journal of Dermatology and Venerology” This study found that androgenetic alopecia is associated with insulin resistance, elevated adipokines levels, and dyslipidemia in males, while female patients generally maintained a normal hormonal profile.
October 2025 in “International Journal of Innovative Research in Technology” In this study from IJIRT, researchers evaluated teaching programs focused on enhancing waste management knowledge among women, assessing the effectiveness of these educational initiatives.
October 2004 in “Australian Prescriber” This article discusses the role of lifestyle changes and medication like metformin in managing insulin resistance and cardiovascular risk in women with polycystic ovary syndrome but reports no new clinical results.
October 2004 in “Australian Prescriber” This discussion reviews the lack of long-term clinical studies on metformin's cardiovascular benefits in women with polycystic ovary syndrome, advocating for lifestyle changes to improve insulin sensitivity.
October 2004 in “Australian Prescriber” This article discusses the management of long-term cardiovascular risks in women with polycystic ovary syndrome and suggests that lifestyle changes may be more effective than metformin in reducing the incidence of type 2 diabetes.
October 2004 in “Australian Prescriber” This article discusses the long-term cardiovascular risks associated with polycystic ovary syndrome and highlights the greater effectiveness of lifestyle changes compared to metformin in preventing type 2 diabetes, but provides no new clinical outcomes.
October 2004 in “Australian Prescriber” This review discusses the management of long-term risks in women with polycystic ovary syndrome, recommending lifestyle changes to improve insulin sensitivity over relying solely on metformin, and reports no new clinical results.
October 2004 in “Australian Prescriber” This article discusses the role of insulin resistance in cardiovascular risk and suggests that lifestyle changes may be more beneficial than metformin in managing polycystic ovary syndrome; it reports no new clinical results.
October 2004 in “Australian Prescriber” This abstract reviews the management of polycystic ovary syndrome and highlights the potential benefits of lifestyle changes over metformin in reducing type 2 diabetes risk, yet reports no new clinical outcomes.
October 2010 in “Cambridge University Press eBooks” This review examines obesity's role in PCOS and reports that obesity treatment guidelines can likely be applied to women with PCOS without substantial changes.