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Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Insulin helps heal corneal wounds and nerves in diabetic mice by activating the Wnt signaling pathway.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

The article concludes that a balance is needed between individual healthcare needs and societal resources when it comes to lifestyle drugs, with a call for compassionate policy application.

Old drugs can be used for new treatments, saving time and money, but there are challenges like needing more evidence and legal concerns.

Beta-blockers and anti-anginal medications have various side effects and interactions that require careful monitoring and individualized treatment.

Lower vaspin levels in the blood may indicate a better response to fertility treatment in women with PCOS.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.

Certain genetic variations in OCT1 may improve insulin sensitivity with metformin in women with PCOS.

Rosuvastatin improves lipid levels, reduces inflammation, but worsens insulin sensitivity in men with early-onset hair loss.

Melatonin may help manage PCOS by improving insulin sensitivity, hormone balance, and mood.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.

Old drugs like finasteride and spironolactone are being successfully used for hair loss and skin conditions, and many other drugs show promise for new uses in dermatology.

Some drugs may increase the risk of obstructive sleep apnea, while others like certain biologics might decrease it.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Modified HDL can better deliver drugs and genes, potentially improving treatments and reducing side effects.

A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

Androgenetic alopecia is linked to higher cardiovascular and metabolic risks, possibly due to irisin resistance.

Polycystic Ovary Syndrome can cause hair loss and skin issues, and early treatment is important for preventing complications.