43 citations
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March 1942 in “The Journal of experimental medicine/The journal of experimental medicine” This study found that mice can synthesize inositol, but this ability is impaired when pantothenic acid is lacking in their diet.
28 citations
,
January 2009 in “Cellular & Molecular Biology Letters” This study concluded that finasteride-induced DHT deficiency intensified constitutive iNOS expression in rat testicular and epididymal cells, suggesting a complex regulatory relationship needing further investigation.
27 citations
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July 1946 in “The journal of nutrition/The Journal of nutrition” This study found that adding inositol or biotin to a pig's diet without sulfathalidine had no effect on growth or feed efficiency, but both helped alleviate deficiency symptoms caused by sulfathalidine.
25 citations
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January 1944 in “Experimental Biology and Medicine” This study found that supplementing inositol in a diet containing sulfasuxidine prevents symmetrical alopecia and promotes better growth and appearance in rats.
25 citations
,
April 1941 in “Experimental biology and medicine” This study found that mice developed alopecia when deficient in pantothenic acid, even when inositol was present.
24 citations
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July 2019 in “Journal of Obstetrics and Gynaecology” This study found that a 12-week supplementation with a combination of insulin sensitizing agents, antioxidants, and vitamins significantly improved menstrual cyclicity, acne, and hirsutism in women with PCOS, with additional weight loss benefits in obese subjects.
20 citations
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November 1943 in “Experimental Biology and Medicine” This study found that inositol supplementation in rats improved growth and prevented hair loss, and combining it with folic acid and B6 resulted in even better growth rates.
18 citations
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October 2017 in “Drug Design Development and Therapy” The study found that finasteride increased endoplasmic reticulum stress and reduced fertility in rats, effects that were alleviated by the administration of DA-9401.
18 citations
,
November 2016 in “International clinical psychopharmacology” This study found that in a 10-week trial, inositol did not significantly reduce trichotillomania symptoms compared to placebo, although 42.1% of inositol-treated patients felt 'much or very much improved' at the study's end.
8 citations
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May 1941 in “Science” Inositol helped cure hair loss around rats' eyes and improved their growth.
3 citations
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May 2018 in “Biochemical and Biophysical Research Communications” In this study, researchers found that inhibiting inducible nitric oxide synthase (iNOS) promoted hair growth in diabetic mice, suggesting iNOS-derived nitric oxide contributes to hair loss under diabetic inflammatory conditions.
3 citations
,
February 1943 in “The American journal of digestive diseases/American journal of digestive diseases” Riboflavin helps heal bed sores, inositol aids skin diseases, and calcium pantothenate doesn't prevent gray hair.
March 2026 in “Physical Education Health and Social Sciences” In this randomized controlled trial, combining cinnamon and inositol led to significant improvements in metabolic and hormonal parameters, such as reduced LH, testosterone, fasting glucose, and ovarian ultrasound scores, in overweight women with PCOS, indicating superior benefits over either supplement alone.
November 2025 in “British Journal of Pharmacology” This study found that inositol hexaphosphate significantly reduced hearing threshold shifts and outer hair cell loss in various sensorineural hearing loss mouse models, suggesting potential for otoprotective use.
June 2024 in “Skin Research and Technology” This study observed that the expression of hsa-miR-193a-5p was significantly higher in alopecia areata patients compared to healthy controls, suggesting its role in influencing disease progression through impact on specific signaling pathways and highlighting its potential as a therapeutic target.
March 2024 in “Romanian Medical Journal” This review examines the administration, efficacy, and potential applications of inositol, highlighting its roles in treating conditions like mental health disorders, metabolic disorders, and PCOS. The authors emphasize the need for further research into inositol's multifaceted therapeutic benefits.
February 2024 in “Biomedical journal of scientific & technical research” This study explored whether inositol and phytic acid, components from rice bran, could be effective and safe alternatives to minoxidil for promoting hair growth, due to concerns about minoxidil's side effects with long-term use in women. Results are not reported.
May 2023 in “Metabolites” In this study, adding α-lactalbumin to myo-inositol treatment improved ovulation rates, menstrual cycle duration, and hyperandrogenism in women with PCOS more effectively than myo-inositol alone, suggesting potential benefits for those resistant to inositol treatment.
May 2022 in “Maǧallaẗ Buḥūṯ Al-Tarbiyyaẗ Al-Nawʿiyyaẗ (Print)” In this study, a high inositol diet, with or without supplements, significantly improved androgen levels, insulin sensitivity, and certain metabolic indicators in women with PCOS over three months.
September 2018 in “Cosmetics” This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.
October 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that finasteride induced infertility and increased endoplasmic reticulum stress in rats, but these effects were mitigated by DA-9401 administration.
August 2015 in “Evidence Based Women Health Journal (Online)” This study found that inositol was significantly more effective than Metformin in promoting weight reduction, spontaneous ovulation, and pregnancy in patients with polycystic ovary syndrome.
May 2015 in “Evidence Based Women Health Journal (Online)” This study found that myoinositol combined with D-chiroinositol was more effective than metformin in improving weight reduction, spontaneous ovulation, and pregnancy rates in women with polycystic ovary syndrome.
June 2018 in “The Journal of Sexual Medicine” In this study, finasteride was found to significantly reduce DHT levels and affect spermatogenic markers in rats, while DA-9401 co-treatment indicated potential ameliorative effects.
December 2015 in “Endocrinology and Metabolic Syndrome” This study observed that treatment with inositol, in various doses based on BMI, led to significant reductions in hair loss and symptoms of hyperandrogenism in patients with androgenetic alopecia.
September 2015 in “Journal of Steroids & Hormonal Science” This study reports a significant reduction in hair loss and other androgen-related signs in hyperandrogenism patients using inositol supplementation, although further research is needed to confirm these findings.
369 citations
,
June 2013 in “Biochimie” This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.
64 citations
,
January 2009 in “Gynecological Endocrinology” This study found that myo-inositol treatment reduced hirsutism and acne in women with PCOS by improving their metabolic profiles, including lower insulin and testosterone levels.
19 citations
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January 2019 in “Ginekologia Polska” This study found that combined Myo-inositol and D-chiro-inositol therapy improved metabolic and hormonal parameters, including weight, hormone levels, and skin conditions, in women with PCOS after 6 months.
11 citations
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January 2024 in “Gynecological Endocrinology” This narrative review on inositol use in PCOS treatment found positive results for myo-inositol alone and effective outcomes for a myo-inositol/D-chiro inositol combination at a 40:1 ratio, suggesting further research on other combinations like 66:1 to 100:1.