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Hair breakage may be an early sign of a hair loss condition called CCCA in African American women.

Horizontal sections of scalp biopsies are good for diagnosing Central Centrifugal Cicatricial Alopecia and help customize treatment.

Lipase H is important for hair follicle function and shaping hair fibers.

Treatments for permanent hair loss from scarring aim to stop further loss, not regrow hair, and vary by condition, with partial success common.

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

The document concludes that accurate diagnosis and treatment of scalp itch require differentiating between various conditions using a proposed five-step evaluation process.

The study found that Central Centrifugal Cicatricial Alopecia mainly affects middle-aged African descent women, is linked to certain hair care practices and genetics, and often goes undiagnosed for years.

Fibrosing alopecia in a pattern distribution is a unique hair loss condition that may respond to antiandrogen therapy.

Lichen planopilaris in men often involves scalp redness and itching, with some also having hair loss, mucosal lichen planus, or thyroid disease, and treatment improved symptoms in nearly half of the cases.

Seborrheic dermatitis may contribute to the development of central centrifugal cicatricial alopecia.

A condition with certain scalp changes may come before acne keloidalis nuchae and other similar hair loss disorders.

CK15 is not a reliable marker for stem cells in damaged hair follicles from patients with CCCA.

Mutant mice help researchers understand hair growth and related genetic factors.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Early shedding of the inner root sheath in noninflamed hair follicles is a relatively specific sign of Central Centrifugal Cicatricial Alopecia.

Cathepsin L is essential for normal hair growth and development.

The document concludes that diagnosing hair loss requires evaluating multiple histological features, as no single feature is definitive on its own.

CCCA may be caused by both hair traction and an immune response.

Recognizing specific features of African-American hair can help diagnose hair loss conditions.

Early and late matrix progenitors in hair follicles create different cell layers, with early ones forming the companion layer and later ones forming the inner root sheath and hair shaft.

Sweat glands and hair follicles are determined by opposing signals, with BMPs promoting sweat glands and blocking BMPs leading to hair follicles.

COX-2 levels change during the hair cycle and affect skin and hair growth.

Tight hairstyles and chemical relaxers can cause hair loss known as traction alopecia.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Chemotherapy and radiation therapy cause skin and hair damage by altering gene expression and signaling pathways.

Chemical hair straighteners can cause scalp and hair damage, but long-term effects are unclear.

The hair cuticle is made of tough proteins that protect the hair, but more research is needed to fully understand its structure.

Hair loss in black women needs more research, early intervention, and community education.

Researchers found a white halo around hair in most patients with a specific type of hair loss, which helps in early diagnosis and treatment.