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November 2024 in “Cutis” PLLA injections can cause hair loss and skin issues.
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April 2024 in “Journal of Pharmaceutical and Pharmacological Sciences” This study evaluated androgen-induced hair loss and anagen induction mouse models, finding that Minoxidil and Pyrilutamide significantly promoted hair growth by decreasing androgen receptor protein levels and enhancing the Wnt/β-Catenin signaling pathway, supporting their use in studying novel treatments for androgenetic alopecia.
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November 2022 in “Journal of Cosmetic Dermatology” This review discusses the possible materials used in subcutaneous injections for alopecia, but it reports no new clinical results and highlights the need for further research.
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March 2022 in “JAAD case reports” This case report describes a rare occurrence of injection site reactions in a 77-year-old woman with eosinophilic fasciitis using subcutaneous methotrexate, marking the first documented instance in this patient population.
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January 2022 in “The Egyptian Journal of Hospital Medicine ” This study found that both superficial cryotherapy and intralesional corticosteroid injections significantly improved hair growth in patients with alopecia areata, with similar efficacy between the two treatments, establishing cryotherapy as a simple and noninvasive treatment option.
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October 2017 in “Animal science journal” This study found that cyclophosphamide treatment in cashmere goats significantly increased cashmere yield by inducing shedding without affecting fiber length, with a 20 mg/kg body weight dose being optimal for hair removal and regrowth.
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January 2010 This study found that using minoxidil 2% as a mesotherapy injection showed more significant improvement in treating androgenetic alopecia in female patients than topical application.
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December 2021 in “Journal of Cosmetic Dermatology” This study observed that COVID-19 is associated with accelerated androgenetic alopecia, and platelet-rich plasma treatment showed improvement in hair loss after infection.
August 2026 in “South Asian Journal of Health Sciences” In this case report, a 35-year-old man developed avascular necrosis after receiving intradermal corticosteroid injections for alopecia areata, marking the first documented instance of this side effect from such treatment.
July 2026 in “Journal of Cutaneous and Aesthetic Surgery” This study found that intralesional Vitamin D3 injections were comparable in efficacy to intralesional triamcinolone for patchy alopecia areata, with a non-significant trend towards better outcomes and fewer local adverse effects.
February 2026 in “Journal of Cosmetic Dermatology” This study found that intradermal polynucleotide injections were linked to improvements in the appearance around the eyes and increased patient satisfaction, with minimal adverse effects, suggesting potential for further research to validate efficacy and optimize treatment protocols.
January 2026 in “BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY” In this randomized controlled trial, both Botulinum Toxin-A and Triamcinolone Acetonide showed substantial effectiveness in treating patchy Alopecia Areata, but Botulinum Toxin-A avoided complications while Triamcinolone led to skin atrophy in 16.7% of patients.
January 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences” In this randomized study, intradermal injections of dutasteride effectively improved androgenetic alopecia in 15 male patients, showing significant clinical improvement within one month and being well-tolerated without notable side effects, though the improvement was negatively correlated with longer disease duration.
November 2025 in “Fayoum University Medical Journal/Fayoum University Medical Journal ” This study found that intralesional vitamin D3 injections significantly increased serum vitamin D3 levels in patients with localized alopecia areata, although baseline vitamin D3 levels did not predict disease severity or treatment response.
June 2025 in “Archives of Dermatological Research” This study found that photobiomodulation-irradiated conditioned medium from human adipose-derived stromal cells enhanced hair growth in mice, suggesting its potential as a treatment for hair loss by increasing growth factor secretion.
May 2025 in “Frontiers in Bioengineering and Biotechnology” In this study, the researchers reported that a novel exosome-based treatment, EX104, effectively reversed hair follicle miniaturization and promoted hair growth in a mouse model of androgenetic alopecia, showing results comparable to minoxidil and surpassing it in stimulating capillary growth and follicular proliferation.
May 2025 in “Oral Sciences Reports” This case study reports that a 45-year-old woman developed a painless nodule in the lower lip four weeks after receiving hyaluronic acid filler, which required surgical removal, highlighting the potential for delayed complications from lip augmentation procedures.
This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.
May 2025 in “Research Square (Research Square)” This study found that conditioned medium from photobiomodulation-irradiated adipose-derived stromal cells enhanced hair growth in a mouse model of hair loss more effectively than non-irradiated medium, suggesting potential for treating alopecia by boosting growth factor secretion.
April 2025 in “Journal of Cosmetic and Laser Therapy” This study found that both microneedle delivery and intradermal injection of platelet-rich plasma were similarly effective for treating androgenetic alopecia, but microneedle delivery caused significantly less pain.
March 2025 in “Archives of Plastic Surgery” This review suggests that combining platelet-rich plasma with microneedling may produce better hair restoration outcomes for androgenetic alopecia than using PRP injections alone, but calls for more standardized research.
January 2025 in “Zagazig University Medical Journal” This study found that nanofat injection before hair transplant may improve the survival of hair grafts in patients with secondary cicatricial alopecia.
Nanofat injection is safe and effective for improving skin texture and patient satisfaction.
November 2024 in “Journal of the European Academy of Dermatology and Venereology” In this pilot study, cryotherapy using a device that precisely controls cooling duration improved hair regrowth for patchy alopecia areata when applied for 20 seconds with two freeze-thaw cycles, similar to standard triamcinolone acetonide injections, but not when applied for 10 seconds.
November 2024 in “Journal of Clinical Medicine” This study observed that six sessions of injections using a stabilized hyaluronic acid compound improved hair thickness, shine, density, and reduced hair loss in volunteers with moderate androgenetic alopecia, with excellent treatment tolerability and high satisfaction reported by 88.5% of participants.
October 2024 in “Zagazig University Medical Journal” This clinical trial found that transdermal delivery of 5-Fluorouracil using fractional CO2 laser resulted in a significantly better treatment response in alopecia areata patients compared to intralesional injections of the same drug, with a greater reduction in the Severity of Alopecia Tool Score.
October 2024 in “Cosmetics” This study found that while most women reported aesthetic improvement after PRP facial injections, objective skin analyzer data showed no significant changes, but midface volume improvement was more likely in those with lower platelet counts and higher estradiol levels.
September 2024 in “Egyptian Journal of Dermatology and Venerology” This study found that intralesional injection of triamcinolone acetonide combined with latanoprost (a PGF2α analog) was more effective in treating localized alopecia areata, showing higher treatment response rates and greater reduction in severity scores compared to other treatments.
June 2024 in “Georgetown Scientific Research Journal” This study found that intradermal bleomycin injections induced dermal fibrosis in C57BL/6 mice, evidenced by hair follicle obliteration and dermal thickening, though no significant trends in gene expression were observed, indicating the need for further research to understand the link between fibrosis and dyschromia.
June 2024 in “Dermatology and therapy” This study reviewed recent advancements in using botulinum toxin for treating androgenetic alopecia and emphasized the need for further research to determine the most effective injection sites and depths, as current strategies show inconsistent results.