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This review examined photothermal hydrogels, biomedically innovative materials responsive to near-infrared stimulation, which hold promise for enhancing infection control and tissue regeneration. The authors highlighted their unique properties, construction methods, and potential applications while also discussing existing challenges and future research directions.

The hydrogel helps heal diabetic wounds by combining antibacterial, antioxidant, and immune-boosting effects.

The hydrogel improves hair growth treatment by enhancing drug delivery and promoting follicle repair.

This study found that a bioprinted hydrogel scaffold with zinc and silicon ions significantly activated hair follicle stem cells and enhanced blood vessel formation, promoting hair growth in mouse wound models.

In this study, researchers developed a dexpanthenol-infused nanotechnological platform within hyaluronic acid hydrogels that promoted wound healing in mice by providing a protective barrier and significantly enhancing skin regeneration, including increased fibroblast activity and tissue remodeling.

This study found that incorporating adipose-derived stem cell conditioned medium into a polysaccharide hydrogel effectively reduced scar hyperplasia, with the combination offering better outcomes in preventing hypertrophic scarring compared to the medium alone in a rabbit ear model.

In a study using female Wistar rats, the researchers found that a liquid allantoin-enriched pectin hydrogel significantly improved wound healing, achieving a 71.43% reduction in healing time and complete wound closure in 15 days.

In this study, a hydrogel with anti-inflammatory, antibacterial, antioxidant, and wound tissue adhesion properties was developed, showing significant potential for wound healing and suggesting it could offer a new and effective treatment option in clinical settings.

This review covers recent developments in materials for in vitro and in vivo stem cell manipulation, highlighting innovative substrate properties but does not report new experimental results.

This review discusses the advantages and progress of chitosan hydrogels in vascular regeneration for tissue engineering scaffolds, highlighting modifications to enhance their application and exploring future prospects.

This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.

This review categorizes contractile hydrogels by their contraction mechanisms and explores their role in advanced wound management, emphasizing mechanical and biochemical signaling in healing, but also notes challenges like force transmission and clinical applicability.

This study developed a multifunctional hydrogel, QTMP-Gel, which significantly accelerated wound healing in an oral mucositis hamster model by providing antioxidant and antibacterial effects, reducing inflammation, and controlling infection.

This study reports that using a hydrogel-based therapy that dynamically regulates reactive oxygen species helps achieve skin regeneration in infected wounds, promoting organized dermal architecture with improved hair follicle and blood vessel formation, rather than scar formation.

This study developed a novel zinc-releasing hydrogel, Zn-Gel, which promoted wound healing by controlling zinc ion release and demonstrated excellent compatibility and efficacy in enhancing cell proliferation, blood vessel formation, and tissue regeneration in vitro and in vivo settings.

This study describes a method to create keratin hydrogels with adjustable erosion rates by mixing different ratios of keratose and kerateine, enabling controlled release of therapeutic agents like insulin-like growth factor 1.

This study found that a novel skin patch combining extracellular matrix and ciprofloxacin promotes advanced wound healing and skin regeneration in mouse models of infected wounds.

The hydrogel is safe, reduces oxidation, and helps heal wounds effectively.

This study found that adding keratin to a collagen hydrogel improved keratinocyte differentiation compared to a pure collagen hydrogel, particularly when calcium was also present in the media.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

This study found that modifying adipose-derived stem cells to overexpress the adhesion protein JAM-A increased the adhesion and resilience of dermal papilla cells in the context of androgenic alopecia, potentially facilitating hair regrowth despite challenges such as damage from dihydrotestosterone and macrophages.

This study found that encapsulating hADSCs-derived exosomes in PF-127 hydrogel improved wound healing in mice, suggesting a promising approach for enhancing skin repair.

This study characterized keratin-based biomaterials that self-assemble into hydrogels, demonstrating their potential to achieve hemostasis in a lethal liver injury model through specific biomaterial-receptor interactions.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This study found that a glucose-activated hydrogel significantly improved chronic diabetic wound healing by regulating blood glucose and enhancing the wound microenvironment, achieving a threefold increase in recovery rate compared to commercial dressings.

This study explored the use of manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and promoting wound healing, finding that these hydrogels effectively ablate melanoma under near-infrared irradiation and enhance vascular endothelial cell activity for tissue regeneration.

This review discusses the potential of hydrogel-based interventions for radiation-induced skin injury, providing no new clinical results but highlighting their synergistic mechanisms and promise in improving treatment strategies.

The hydrogel dressing effectively treats infected wounds by combining infection control and tissue regeneration.

The hydrogel helps heal seawater-immersed wounds by reducing infection and inflammation.

This study developed a closed-loop system for emergency wound care that monitors infection in real-time using biomarkers and delivers amikacin-loaded liposomes for treatment, integrating a conductive hydrogel for environmental protection and antibacterial benefits.