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    Research 241–270 of 1000+

    1. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007 · 195 citations
    2. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015 · 184 citations
    3. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    4. Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control Experimental Dermatology · 2005 · 127 citations
    5. Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P The FASEB Journal · 2001 · 125 citations
    6. Comparison of finasteride (proscar®), a 5α reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5α reductase inhibition The Prostate · 1993 · 124 citations
    7. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder Neuropsychopharmacology · 2015 · 110 citations
    8. The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer 2008 · 108 citations
    9. Androgen receptor–mediated inhibition of cutaneous wound healing 2002 · 108 citations
    10. Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition Journal of Molecular Medicine · 2005 · 76 citations
    11. Outcome of long-term treatment with the 5α-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up Fertility and Sterility · 1996 · 75 citations
    12. Post-tyrosinase Inhibition of Melanogenesis by Melatonin in Hair Follicles in Vitro Journal of Investigative Dermatology · 1980 · 75 citations
    13. Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells 2009 · 70 citations
    14. 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment Journal of Ethnopharmacology · 2011 · 69 citations
    15. Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome Nature Clinical Practice Endocrinology & Metabolism · 2005 · 69 citations
    16. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    17. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    18. Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures PLoS ONE · 2013 · 60 citations
    19. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    20. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism · 1994 · 59 citations
    21. CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane‐induced alopecia EMBO Molecular Medicine · 2019 · 58 citations
    22. Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice Scientific reports · 2016 · 58 citations
    23. DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration PLOS ONE · 2010 · 56 citations
    24. Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. PubMed · 1999 · 48 citations
    25. Hair growth inhibition by heparin in mice: a model system for studying the modulation of epithelial cell growth by glycosaminoglycans? British Journal of Dermatology · 1991 · 46 citations
    26. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    27. Anabolic effects of testosterone are preserved during inhibition of 5α-reductase 2007 · 42 citations
    28. Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation 1998 · 42 citations
    29. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    30. Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation Journal of Cellular Biochemistry · 2011 · 37 citations