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Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.

Laminin 332 is essential for normal skin cell behavior and structure.

Keratosis pilaris is a common skin condition where hair follicles get clogged with keratin, mostly on the arms and thighs.

FoxN1 overexpression in young mice harms immune cell and skin development.

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

Prolactin and TGF-β receptor blockers might help treat hair loss.

High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.

Astrotactin2 affects hair follicle orientation and skin cell polarity.

Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

Mutant mice help researchers understand hair growth and related genetic factors.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

DHT, a testosterone byproduct, causes male pattern baldness.

HIV can cause unusual and severe skin problems that are hard to treat.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.

Hair loss in women often doesn't follow a pattern, isn't linked to age, may be genetic, and can be related to thyroid issues or other health factors.

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

Stress can worsen skin conditions and affect mental health, so doctors should include stress management in skin treatment.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

Most skin diseases in Hajjah, Yemen, were dermatitis, infections, and acne, influenced by local socioeconomic and environmental factors.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

The HOXC13 gene affects different hair proteins in cashmere goats in varied ways and is controlled by a feedback loop and other factors.

Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.