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Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Allergic reactions to blood thinners are rare but can be serious, requiring careful testing and alternative treatments.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Finasteride effectively treats baldness but may cause sexual side effects.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Finasteride may cause long-lasting sexual side effects.

Microneedling is promising for treating various skin issues but needs more research to confirm its effectiveness and safety.

Foals with Rhodococcus equi infection often have other health problems that lower their chances of survival.

PLD is an effective and safer alternative for treating breast cancer.

Interferon, especially alfa interferon, is an effective treatment for cutaneous T-cell lymphoma with manageable side effects.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

No treatment fully prevents hair loss from chemotherapy yet.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Prolactin affects hair growth cycles and can cause early hair follicle regression.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

New antifungal treatments for a children's scalp infection are effective and safe, but it's not decided if they will become the preferred option over the old treatment.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.