157 citations
,
May 2021 in “Endocrine Reviews” This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.
114 citations
,
March 2021 in “Scientific Reports” This study found that, among COVID-19 patients in South Korea, hypertension, diabetes, and other comorbidities significantly increased mortality risk, with the age-adjusted Charlson comorbidity index being a strong predictor of death.
84 citations
,
December 2018 in “Genetics in Medicine” This article reviews evidence- and consensus-based recommendations for using pegvaliase in adults with PKU and reports no new clinical results.
68 citations
,
September 2018 in “International Journal of Molecular Sciences” In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.
65 citations
,
April 2020 in “International Journal of Molecular Sciences” This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.
58 citations
,
June 2018 in “Scientific reports” This study identified novel genetic associations with skin phenotypes such as age-spots, freckles, and hair characteristics in Japanese women, providing insights into the genetic basis of these traits.
52 citations
,
June 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study defined menstrual phase-specific reference intervals for circulating androgen levels in young women, highlighting that anovulatory females showed higher androgen, LH, and FSH levels compared to ovulatory females.
49 citations
,
April 2016 in “International journal of molecular sciences” This study found that shift nurses exhibited lower circadian variations compared to daytime nurses, indicating an adjustment of their biological clocks to continuous shift schedules.
48 citations
,
June 2013 in “Journal of Dermatological Science” This study found that valproic acid promoted human hair growth by increasing β-catenin levels, suggesting it may be a potential therapeutic option for alopecia.
47 citations
,
May 2021 in “Polymers” This review surveys the chemical composition and various uses of jojoba oil in medicine and industry but presents no new clinical results.
43 citations
,
March 2011 in “Journal of psychosomatic research” This study found that children with alopecia areata experienced more stressful life events and excreted higher levels of catecholamines compared to healthy siblings.
42 citations
,
September 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS who have an exaggerated 17-hydroxyprogesterone response to buserelin exhibit more severe hyperandrogenemia, increased insulin secretion, and reduced insulin sensitivity.
37 citations
,
September 2017 in “Reumatología Clínica” In this systematic review and meta-analysis, methotrexate and leflunomide were compared for treating rheumatoid arthritis, showing similar efficacy overall. Methotrexate reduced swollen joints more effectively, while leflunomide was associated with fewer gastrointestinal side effects but more frequent liver enzyme increases.
28 citations
,
January 2006 in “Journal of agricultural safety and health” This study found that skin disease, particularly fungal infections, is prevalent among Latino farmworkers in North Carolina, with no significant differences observed between workers at two different camps.
27 citations
,
June 2019 in “Aesthetic Plastic Surgery” Platelet-Rich Plasma (PRP) treatment may increase hair growth for genetic hair loss, but more research is needed to confirm this.
27 citations
,
April 2018 in “Scientific Reports” This study found that in psoriasis patients, the K17 protein probably functions as an autoantigen, with the HLA-Cw*06:02 risk genotype strongly linked to the T cell response size.
26 citations
,
November 2009 in “Journal of Endocrinological Investigation” This study found no significant difference in the CAG and GGN repeat lengths between infertile and fertile men in Nigeria, but identified a unique GGN allele distribution in the Nigerian population compared to Caucasians.
25 citations
,
August 2017 in “Lasers in Medical Science” This literature review reported that fractional lasers, like the 1550-nm nonablative erbium-glass laser, may enhance hair regrowth by stimulating a wound healing process, but more randomized controlled trials are needed to confirm their effectiveness and optimize treatment parameters.
23 citations
,
August 2017 in “Scientific Reports” Darker hair may lead to higher cortisol readings, suggesting a need to adjust for hair color in studies.
21 citations
,
May 2021 in “Patient education and counseling” This study explored the challenges faced by both clinicians and women with polycystic ovary syndrome in managing the condition, highlighting issues with treatment options, misinformation, and differing expectations in care.
21 citations
,
December 2012 in “Maturitas” This study observed significant inter- and intra-individual variability in serum testosterone levels among women treated with subcutaneous testosterone implants, suggesting that therapy should be guided by clinical response rather than single serum measurements.
20 citations
,
October 2018 in “Clinical Drug Investigation” This study observed that men receiving dutasteride for benign prostatic hyperplasia did not show significant differences in neuropsychological assessments compared to a control group not on dutasteride.
19 citations
,
January 2018 in “BioMed Research International” This study suggests that miRNAs, particularly miR-195-5p, may regulate the loss of hair follicle inductivity in cultured dermal papilla cells by suppressing the Wnt/β-catenin pathway.
19 citations
,
December 2016 in “PLOS ONE” This study found that proteins secreted by early-passage dermal papilla cells, including SDF1, MMP3, biglycan, and LTBP1, may play significant roles in hair follicle regeneration.
17 citations
,
March 2016 in “Liver international” This study found that low serum testosterone and elevated serum oestrone in men with cirrhosis are associated with worse liver disease and adverse health outcomes, suggesting oestrone as a potential ill health marker.
15 citations
,
March 2014 in “General Hospital Psychiatry” The study found that patients with schizophrenia have a higher prevalence of skin diseases than those without, highlighting the importance of proper skin care in this population.
14 citations
,
February 2023 in “Frontiers in immunology” This review discusses the range of cutaneous immune-related adverse events induced by immune checkpoint inhibitors and the proposed mechanisms underlying these skin reactions, but reports no new clinical results.
14 citations
,
May 2021 in “Marine Drugs” This review discusses the therapeutic properties of polydeoxyribonucleotides derived from marine organisms for wound healing and inflammation, but it reports no new clinical results.
14 citations
,
April 2021 in “Frontiers in Psychiatry” This study found that during the Covid-19 lockdown, the percentage of abstinent and low-risk alcohol drinkers increased while moderate and chronic drinking decreased compared to the previous four years.
14 citations
,
November 2016 in “Annals of Internal Medicine” Tofacitinib, an arthritis drug, helped hair growth in alopecia universalis but long-term safety needs more research.